Cover Image

Vitamin D-binding protein, bioavailable, and free 25(OH)D, and mortality: a systematic review and meta-analysis

Introduction: Observational studies reported inverse associations between serum total 25-hydroxyvitamin D (25(OH)D) concentrations and mortality. Evolving evidence indicated, however, that bioavailable or free 25(OH)D may be even better predictors of mortality. We conducted a systematic review and m...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhu, Anna (Author) , Kuznia, Sabine (Author) , Boakye, Daniel (Author) , Schöttker, Ben (Author) , Brenner, Hermann (Author)
Format: Article (Journal)
Language:English
Published: 20 September 2022
In: Nutrients
Year: 2022, Volume: 14, Issue: 19, Pages: 1-15
ISSN:2072-6643
DOI:10.3390/nu14193894
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/nu14193894
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6643/14/19/3894
Get full text
Author Notes:Anna Zhu, Sabine Kuznia, Daniel Boakye, Ben Schöttker and Hermann Brenner
Description
Summary:Introduction: Observational studies reported inverse associations between serum total 25-hydroxyvitamin D (25(OH)D) concentrations and mortality. Evolving evidence indicated, however, that bioavailable or free 25(OH)D may be even better predictors of mortality. We conducted a systematic review and meta-analysis to summarize the epidemiological evidence on associations of vitamin D-binding protein (VDBP), albumin-bound, bioavailable, and free 25(OH)D, with mortality. Methods: We systematically searched PubMed and Web of Science, up to 27 May 2022. Predictors of interest included serum or plasma concentrations of VDBP, albumin-bound, bioavailable, and free 25(OH)D. Assessed health outcomes were all-cause and cause-specific mortality. We included studies reporting associations between these biomarkers and mortality outcomes. We applied random-effects models for meta-analyses to summarize results from studies assessing the same vitamin D biomarkers and mortality outcomes. Results: We identified twelve eligible studies, including ten on VDBP, eight on bioavailable 25(OH)D, and eight on free 25(OH)D. No study reported on albumin-bound 25(OH)D and mortality. In meta-analyses, the highest levels of bioavailable and free 25(OH)D were associated with 37% (hazard ratio (HR): 0.63, 95% confidence interval (CI): 0.46, 0.87), and 29% (HR: 0.71, 95% CI: 0.53, 0.97) decrease in all-cause mortality, respectively, compared with the lowest levels. These estimates were similar to those for total 25(OH)D (HR: 0.67, 95% CI: 0.56, 0.80) observed in the same studies. Higher VDBP levels were associated with lower all-cause mortality in cancer patient cohorts. However, no such association was observed in general population cohorts. Conclusions: Similar inverse associations of total, bioavailable, and free 25(OH)D with mortality suggest that bioavailable and free 25(OH)D do not provide incremental value in predicting mortality.
Item Description:Gesehen am 13.12.2022
Physical Description:Online Resource
ISSN:2072-6643
DOI:10.3390/nu14193894

Similar Items