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Proximal neuropathic lesions in distal symmetric diabetic polyneuropathy: findings of high-resolution magnetic resonance neurography

OBJECTIVE: This study investigated high-resolution magnetic resonance neurography (MRN) in distal symmetric diabetic polyneuropathy (dPNP). - RESEARCH DESIGN AND METHODS: MRN comprised high-resolution transaxial imaging of peripheral nerves of the lower limbs in 20 patients with type 2 diabetes (10...

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Main Authors: Pham, Mirko (Author) , Oikonomou, Dimitrios (Author) , Bäumer, Philipp (Author) , Bierhaus, Angelika (Author) , Heiland, Sabine (Author) , Humpert, Per Magnus (Author) , Nawroth, Peter Paul (Author) , Bendszus, Martin (Author)
Format: Article (Journal)
Language:English
Published: February 17, 2011
In: Diabetes care
Year: 2011, Volume: 34, Issue: 3, Pages: 721-723
ISSN:1935-5548
DOI:10.2337/dc10-1491
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2337/dc10-1491
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Author Notes:Mirko Pham, Dimitrios Oikonomou, Philipp Bäumer, Angelika Bierhaus, Sabine Heiland, Per M. Humpert, Peter P. Nawroth, Martin Bendszus
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Summary:OBJECTIVE: This study investigated high-resolution magnetic resonance neurography (MRN) in distal symmetric diabetic polyneuropathy (dPNP). - RESEARCH DESIGN AND METHODS: MRN comprised high-resolution transaxial imaging of peripheral nerves of the lower limbs in 20 patients with type 2 diabetes (10 with dPNP, type 2/dPNP[+], and 10 without dPNP, type 2/dPNP[-]), seven patients with type 1 diabetes (two with dPNP, type 1/dPNP[+], five without dPNP, type 1/dPNP[-]), and 10 nondiabetic control subjects. Intraneural T2 lesions, as the main diagnostic criterion of MRN, were detected visually by two independent observers and quantitatively by analysis of T2 contrast ratios. - RESULTS: Multifocal fascicular, symmetric intraneural T2 lesions occurred in the proximal trunks of sciatic nerves in four patients (three with type 2/dPNP[+] and one with type 1/dPNP[+]) but not in control subjects (type 2/dPNP[-], type 1/dPNP[-], nondiabetic control subjects), which was confirmed by quantitative analysis. Clinical severity was higher in patients with T2 lesions (neuropathy deficit score: 10 vs. 7.8; P = 0.05). - CONCLUSIONS: For the first time, proximal neuropathic lesions of dPNP are reported in vivo. This supports that accumulation of proximal, multifocal fascicular injury may be important in disease progression.
Item Description:Gesehen am 14.12.2022
Physical Description:Online Resource
ISSN:1935-5548
DOI:10.2337/dc10-1491

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