Proximal neuropathic lesions in distal symmetric diabetic polyneuropathy: findings of high-resolution magnetic resonance neurography
OBJECTIVE: This study investigated high-resolution magnetic resonance neurography (MRN) in distal symmetric diabetic polyneuropathy (dPNP). - RESEARCH DESIGN AND METHODS: MRN comprised high-resolution transaxial imaging of peripheral nerves of the lower limbs in 20 patients with type 2 diabetes (10...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 17, 2011
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| In: |
Diabetes care
Year: 2011, Jahrgang: 34, Heft: 3, Pages: 721-723 |
| ISSN: | 1935-5548 |
| DOI: | 10.2337/dc10-1491 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2337/dc10-1491
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| Verfasserangaben: | Mirko Pham, Dimitrios Oikonomou, Philipp Bäumer, Angelika Bierhaus, Sabine Heiland, Per M. Humpert, Peter P. Nawroth, Martin Bendszus |
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| 245 | 1 | 0 | |a Proximal neuropathic lesions in distal symmetric diabetic polyneuropathy |b findings of high-resolution magnetic resonance neurography |c Mirko Pham, Dimitrios Oikonomou, Philipp Bäumer, Angelika Bierhaus, Sabine Heiland, Per M. Humpert, Peter P. Nawroth, Martin Bendszus |
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| 520 | |a OBJECTIVE: This study investigated high-resolution magnetic resonance neurography (MRN) in distal symmetric diabetic polyneuropathy (dPNP). - RESEARCH DESIGN AND METHODS: MRN comprised high-resolution transaxial imaging of peripheral nerves of the lower limbs in 20 patients with type 2 diabetes (10 with dPNP, type 2/dPNP[+], and 10 without dPNP, type 2/dPNP[-]), seven patients with type 1 diabetes (two with dPNP, type 1/dPNP[+], five without dPNP, type 1/dPNP[-]), and 10 nondiabetic control subjects. Intraneural T2 lesions, as the main diagnostic criterion of MRN, were detected visually by two independent observers and quantitatively by analysis of T2 contrast ratios. - RESULTS: Multifocal fascicular, symmetric intraneural T2 lesions occurred in the proximal trunks of sciatic nerves in four patients (three with type 2/dPNP[+] and one with type 1/dPNP[+]) but not in control subjects (type 2/dPNP[-], type 1/dPNP[-], nondiabetic control subjects), which was confirmed by quantitative analysis. Clinical severity was higher in patients with T2 lesions (neuropathy deficit score: 10 vs. 7.8; P = 0.05). - CONCLUSIONS: For the first time, proximal neuropathic lesions of dPNP are reported in vivo. This supports that accumulation of proximal, multifocal fascicular injury may be important in disease progression. | ||
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Diabetic Neuropathies | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Magnetic Resonance Imaging | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Polyneuropathies | |
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