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Anti-Ma2/Ta antibodies in a woman with primary lateral sclerosis-like phenotype and Sjögren syndrome

Anti-Ma2/Ta antibodies are rare paraneoplastic antibodies, which are mostly associated with limbic encephalitis in male patients with testicular cancer. We report on a 50-year-old woman with a pure progressive spastic paraparesis. Next, she was diagnosed as having a Sjögren syndrome, with serologic...

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Hauptverfasser: Piccolo, Giovanni (Verfasst von) , Tavazzi, Eleonora (Verfasst von) , Jarius, Sven (Verfasst von) , Alfonsi, Enrico (Verfasst von) , Cavagna, Lorenzo (Verfasst von) , Piccolo, Laura (Verfasst von) , Zardini, Elisabetta (Verfasst von) , Voltz, Raymond (Verfasst von) , Franciotta, Diego (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 3 March 2011
In: Neurological sciences
Year: 2011, Jahrgang: 32, Heft: 5, Pages: 915-917
ISSN:1590-3478
DOI:10.1007/s10072-011-0510-y
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10072-011-0510-y
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Verfasserangaben:Giovanni Piccolo, Eleonora Tavazzi, Sven Jarius, Enrico Alfonsi, Lorenzo Cavagna, Laura Piccolo, Elisabetta Zardini, Raymond Voltz, Diego Franciotta
Beschreibung
Zusammenfassung:Anti-Ma2/Ta antibodies are rare paraneoplastic antibodies, which are mostly associated with limbic encephalitis in male patients with testicular cancer. We report on a 50-year-old woman with a pure progressive spastic paraparesis. Next, she was diagnosed as having a Sjögren syndrome, with serological positivity for anti-SS-Ro antibodies. The patient’s serum and cerebrospinal fluid samples were positive for anti-Ma2/Ta antibodies, which were also proved to be intrathecally produced. These findings, and the coexistence of systemic autoimmunity, led us to treat the patient with corticosteroids first, and then with plasma exchange. Neurological symptoms scarcely responded to both the therapies. The search for cancer was negative up to 4 years after the disease onset. Our case expands the spectrum of clinical syndromes associated with anti-Ma2/Ta antibodies.
Beschreibung:Gesehen am 14.12.2022
Beschreibung:Online Resource
ISSN:1590-3478
DOI:10.1007/s10072-011-0510-y

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