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A C3-symmetrical chiral trisoxazoline zinc complex as a functional model for zinc hydrolases: kinetic resolution of racemic chiral esters by transesterification

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Mimicking the activity of tris(histidine)zinc-based enzymes, chiral dinuclear trisoxazolinezinc complexes such as the triflato cation (see picture) are the first non-enzymatic catalysts for the asymmetric transesterification of activated esters. First results of the kinetic resolution of amino acid...

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Bibliographic Details
Main Authors: Dro, Clémence (Author) , Bellemin-Laponnaz, Stéphane (Author) , Welter, Richard (Author) , Gade, Lutz H. (Author)
Format: Article (Journal)
Language:English
Published: 25 August 2004
In: Angewandte Chemie. International edition
Year: 2004, Volume: 43, Issue: 34, Pages: 4479-4482
ISSN:1521-3773
DOI:10.1002/anie.200460187
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/anie.200460187
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.200460187
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Author Notes:Clémence Dro, Stéphane Bellemin-Laponnaz, Richard Welter, and Lutz H. Gade
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Summary:Mimicking the activity of tris(histidine)zinc-based enzymes, chiral dinuclear trisoxazolinezinc complexes such as the triflato cation (see picture) are the first non-enzymatic catalysts for the asymmetric transesterification of activated esters. First results of the kinetic resolution of amino acid phenolates establish the stereoselectivity for this reaction. (F pink, N blue, O red, S yellow, Zn cyan)
Item Description:Gesehen am 16.12.2022
Physical Description:Online Resource
ISSN:1521-3773
DOI:10.1002/anie.200460187

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