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A polymorphism within the connective tissue growth factor (CTGF) gene has no effect on non-invasive markers of beta-cell area and risk of type 2 diabetes

Chromosomal locus 6q23 is strongly linked to type 2 diabetes (T2DM) and related features including insulin secretion in various ethnic populations. Connective tissue growth factor (CTGF) gene is an interesting T2DM candidate gene in this chromosome region. CTGF is a key mediator of progressive pancr...

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Main Authors: Pivovarova-Ramich, Olga (Author) , Fisher, Eva (Author) , Dudziak, Katarzyna (Author) , Ilkavets, Iryna (Author) , Dooley, Steven (Author) , Slominsky, Petr (Author) , Limborska, Svetlana (Author) , Weickert, Martin O. (Author) , Spranger, Joachim (Author) , Fritsche, Andreas (Author) , Boeing, Heiner (Author) , Pfeiffer, Andreas F. H. (Author) , Rudovich, Natalia (Author)
Format: Article (Journal)
Language:English
Published: 1 November 2011
In: Disease markers
Year: 2011, Volume: 31, Issue: 4, Pages: 241-246
ISSN:1875-8630
DOI:10.3233/DMA-2011-0823
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3233/DMA-2011-0823
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Author Notes:Olga Pivovarova, Eva Fisher, Katarzyna Dudziak, Iryna Ilkavets, Steven Dooley, Petr Slominsky, Svetlana Limborska, Martin O. Weickert, Joachim Spranger, Andreas Fritsche, Heiner Boeing, Andreas F.H. Pfeiffer and Natalia Rudovich
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Summary:Chromosomal locus 6q23 is strongly linked to type 2 diabetes (T2DM) and related features including insulin secretion in various ethnic populations. Connective tissue growth factor (CTGF) gene is an interesting T2DM candidate gene in this chromosome region. CTGF is a key mediator of progressive pancreatic fibrosis up-regulated in type 2 diabetes. In contrast, CTGF inactivation in mice compromises islet cell proliferation during embryogenesis. The aim of our study was to investigate an impact of CTGF genetic variation on pancreatic beta-cell function and T2DM pathogenesis. We studied the effect of a common CTGF polymorphism rs9493150 on the risk of the T2DM development in three independent German cohorts. Specifically, the association between CTGF polymorphism and non-invasive markers of beta-cell area derived from oral glucose tolerance test was studied in subjects without diabetes. Neither in the Metabolic Syndrome Berlin Potsdam (MESYBEPO) study (n=1026) (OR=0.637, CI (0.387-1.050); p=0.077) nor in the European Prospective Investigation into Cancer and Nutrition-Potsdam (EPIC-Potsdam) (n=3049) cohort (RR=0.77 CI (0.49-1.20), p=0.249 for the recessive homozygote in general model), a significant association with increased diabetes risk was observed. The risk allele of rs9493150 had also no effect on markers of beta-cell area in the combined analysis of the MESYBEPO and Tübingen Family Study (n=1826). In conclusion, the polymorphism rs9493150 in the 5'-untranslated region of the CTGF gene has no association with T2DM risk and surrogate markers of beta-cell area.
Item Description:Gesehen am 19.12.2022
Physical Description:Online Resource
ISSN:1875-8630
DOI:10.3233/DMA-2011-0823

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