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Cathepsin S levels and survival among patients with non-ST-segment elevation acute coronary syndromes

Patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are at high residual risk for long-term cardiovascular (CV) mortality. Cathepsin S (CTSS) is a lysosomal cysteine protease with elastolytic and collagenolytic activity that has been involved in atherosclerotic plaque rupture....

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Main Authors: Stamatelopoulos, Kimon (Author) , Müller-Hennessen, Matthias (Author) , Georgiopoulos, Georgios (Author) , Lopez-Ayala, Pedro (Author) , Sachse, Marco (Author) , Vlachogiannis, Nikolaos I. (Author) , Sopova, Kateryna (Author) , Delialis, Dimitrios (Author) , Bonini, Francesca (Author) , Patras, Raphael (Author) , Ciliberti, Giorgia (Author) , Vafaie, Mehrshad (Author) , Biener, Moritz (Author) , Boeddinghaus, Jasper (Author) , Nestelberger, Thomas (Author) , Koechlin, Luca (Author) , Tual-Chalot, Simon (Author) , Kanakakis, Ioannis (Author) , Gatsiou, Aikaterini (Author) , Katus, Hugo (Author) , Spyridopoulos, Ioakim (Author) , Mueller, Christian (Author) , Giannitsis, Evangelos (Author) , Stellos, Konstantinos (Author)
Format: Article (Journal)
Language:English
Published: 29 August 2022
In: Journal of the American College of Cardiology
Year: 2022, Volume: 80, Issue: 10, Pages: 998-1010
ISSN:1558-3597
DOI:10.1016/j.jacc.2022.05.055
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jacc.2022.05.055
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0735109722054699
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Author Notes:Kimon Stamatelopoulos, Matthias Mueller-Hennessen, Georgios Georgiopoulos, Pedro Lopez-Ayala, Marco Sachse, Nikolaos I. Vlachogiannis, Kateryna Sopova, Dimitrios Delialis, Francesca Bonini, Raphael Patras, Giorgia Ciliberti, Mehrshad Vafaie, Moritz Biener, Jasper Boeddinghaus, Thomas Nestelberger, Luca Koechlin, Simon Tual-Chalot, Ioannis Kanakakis, Aikaterini Gatsiou, Hugo Katus, Ioakim Spyridopoulos, Christian Mueller, Evangelos Giannitsis, Konstantinos Stellos
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Summary:Patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are at high residual risk for long-term cardiovascular (CV) mortality. Cathepsin S (CTSS) is a lysosomal cysteine protease with elastolytic and collagenolytic activity that has been involved in atherosclerotic plaque rupture. The purpose of this study was to determine the following: 1) the prognostic value of circulating CTSS measured at patient admission for long-term mortality in NSTE-ACS; and 2) its additive value over the GRACE (Global Registry of Acute Coronary Events) risk score.
Item Description:Gesehen am 20.12.2022
Physical Description:Online Resource
ISSN:1558-3597
DOI:10.1016/j.jacc.2022.05.055

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