Cathepsin S levels and survival among patients with non-ST-segment elevation acute coronary syndromes

Patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are at high residual risk for long-term cardiovascular (CV) mortality. Cathepsin S (CTSS) is a lysosomal cysteine protease with elastolytic and collagenolytic activity that has been involved in atherosclerotic plaque rupture....

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Hauptverfasser: Stamatelopoulos, Kimon (VerfasserIn) , Müller-Hennessen, Matthias (VerfasserIn) , Georgiopoulos, Georgios (VerfasserIn) , Lopez-Ayala, Pedro (VerfasserIn) , Sachse, Marco (VerfasserIn) , Vlachogiannis, Nikolaos I. (VerfasserIn) , Sopova, Kateryna (VerfasserIn) , Delialis, Dimitrios (VerfasserIn) , Bonini, Francesca (VerfasserIn) , Patras, Raphael (VerfasserIn) , Ciliberti, Giorgia (VerfasserIn) , Vafaie, Mehrshad (VerfasserIn) , Biener, Moritz (VerfasserIn) , Boeddinghaus, Jasper (VerfasserIn) , Nestelberger, Thomas (VerfasserIn) , Koechlin, Luca (VerfasserIn) , Tual-Chalot, Simon (VerfasserIn) , Kanakakis, Ioannis (VerfasserIn) , Gatsiou, Aikaterini (VerfasserIn) , Katus, Hugo (VerfasserIn) , Spyridopoulos, Ioakim (VerfasserIn) , Mueller, Christian (VerfasserIn) , Giannitsis, Evangelos (VerfasserIn) , Stellos, Konstantinos (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 29 August 2022
In: Journal of the American College of Cardiology
Year: 2022, Jahrgang: 80, Heft: 10, Pages: 998-1010
ISSN:1558-3597
DOI:10.1016/j.jacc.2022.05.055
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jacc.2022.05.055
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0735109722054699
Volltext
Verfasserangaben:Kimon Stamatelopoulos, Matthias Mueller-Hennessen, Georgios Georgiopoulos, Pedro Lopez-Ayala, Marco Sachse, Nikolaos I. Vlachogiannis, Kateryna Sopova, Dimitrios Delialis, Francesca Bonini, Raphael Patras, Giorgia Ciliberti, Mehrshad Vafaie, Moritz Biener, Jasper Boeddinghaus, Thomas Nestelberger, Luca Koechlin, Simon Tual-Chalot, Ioannis Kanakakis, Aikaterini Gatsiou, Hugo Katus, Ioakim Spyridopoulos, Christian Mueller, Evangelos Giannitsis, Konstantinos Stellos
Beschreibung
Zusammenfassung:Patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are at high residual risk for long-term cardiovascular (CV) mortality. Cathepsin S (CTSS) is a lysosomal cysteine protease with elastolytic and collagenolytic activity that has been involved in atherosclerotic plaque rupture. The purpose of this study was to determine the following: 1) the prognostic value of circulating CTSS measured at patient admission for long-term mortality in NSTE-ACS; and 2) its additive value over the GRACE (Global Registry of Acute Coronary Events) risk score.
Beschreibung:Gesehen am 20.12.2022
Beschreibung:Online Resource
ISSN:1558-3597
DOI:10.1016/j.jacc.2022.05.055