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Topical systems for the controlled release of antineoplastic drugs: oxidized alginate-gelatin hydrogel/unilamellar vesicles

The efficacy of chemotherapeutic procedures relies on delivering proper concentrations of anti-cancer drugs in the tumor surroundings, so as to prevent potential side effects on healthy tissues. Novel drug carrier platforms should not just be able to deliver anticancer molecules, but also allow for...

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Hauptverfasser: Stagnoli, Soledad (VerfasserIn) , Garro, Cintia (VerfasserIn) , Ertekin, Ozlem (VerfasserIn) , Heid, Susanne (VerfasserIn) , Seyferth, Stefan (VerfasserIn) , Soria, Gastón (VerfasserIn) , Mariano Correa, N. (VerfasserIn) , Leal-Egaña, Aldo (VerfasserIn) , Boccaccini, Aldo R. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 28 August 2022
In: Journal of colloid and interface science
Year: 2023, Jahrgang: 629, Pages: 1066-1080
ISSN:1095-7103
DOI:10.1016/j.jcis.2022.08.163
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jcis.2022.08.163
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0021979722015442
Volltext
Verfasserangaben:Soledad Stagnoli, Cintia Garro, Ozlem Ertekin, Susanne Heid, Stefan Seyferth, Gastón Soria, N. Mariano Correa, Aldo Leal-Egaña, Aldo R. Boccaccini
Beschreibung
Zusammenfassung:The efficacy of chemotherapeutic procedures relies on delivering proper concentrations of anti-cancer drugs in the tumor surroundings, so as to prevent potential side effects on healthy tissues. Novel drug carrier platforms should not just be able to deliver anticancer molecules, but also allow for adjustements in the way these drugs are administered to the patients. We developed a system for delivering water-insoluble drugs, based on the use of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), or bis(2-ethylhexyl) sulfosuccinate benzyl-n-hexadecyldimethylammonium (BHD-AOT), embedded into oxidized alginate-gelatin (ADA/Gel) hydrogel, emulating a patch for topic applications. After being loaded with curcumin, cancer cells such as human colorectal adenocarcinoma (HCT116 and DLD-1) and melanoma cell lines (MEL501), and non-malignant cells such as mammary epithelial cell lines (NMuMG) and embryonal fibroblasts (NIH 3T3 or NEO cells) were analyzed for biocompatibility and cytotoxic effects.
Beschreibung:Version vom 29. September 2022
Gesehen am 20.12.2022
Beschreibung:Online Resource
ISSN:1095-7103
DOI:10.1016/j.jcis.2022.08.163

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