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Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication

It was recently reported that inhibitory molecules such as programmed death-1 (PD-1) were upregulated on CD8+ T cells during acute Friend retrovirus infection and that the cells were prematurely exhausted and dysfunctional in vitro. The current study confirms that most activated CD8+ T cells upregul...

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Main Authors: Zelinskyy, Gennadiy (Author) , Myers, Lara (Author) , Dietze, Kirsten K. (Author) , Gibbert, Kathrin (Author) , Roggendorf, Michael (Author) , Liu, Jia (Author) , Lu, Mengji (Author) , Kraft, Anke R. (Author) , Teichgräber, Volker (Author) , Hasenkrug, Kim J. (Author) , Dittmer, Ulf (Author)
Format: Article (Journal)
Language:English
Published: October 01, 2011
In: The journal of immunology
Year: 2011, Volume: 187, Issue: 7, Pages: 3730-3737
ISSN:1550-6606
DOI:10.4049/jimmunol.1101612
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.1101612
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Author Notes:Gennadiy Zelinskyy, Lara Myers, Kirsten K. Dietze, Kathrin Gibbert, Michael Roggendorf, Jia Liu, Mengji Lu, Anke R. Kraft, Volker Teichgräber, Kim J. Hasenkrug, and Ulf Dittmer
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Summary:It was recently reported that inhibitory molecules such as programmed death-1 (PD-1) were upregulated on CD8+ T cells during acute Friend retrovirus infection and that the cells were prematurely exhausted and dysfunctional in vitro. The current study confirms that most activated CD8+ T cells upregulated expression of PD-1 during acute infection and revealed a dichotomy of function between PD-1hi and PD-1lo subsets. More PD-1lo cells produced antiviral cytokines such as IFN-γ and TNF-α, whereas more PD-1hi cells displayed characteristics of cytotoxic effectors such as production of granzymes and surface expression of CD107a. Importantly, CD8+ T cells mediated rapid in vivo cytotoxicity and were critical for control of acute Friend virus replication. Thus, direct ex vivo analyses and in vivo experiments revealed high CD8+ T cell functionality and indicate that PD-1 expression during acute infection is not a marker of T cell exhaustion.
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Physical Description:Online Resource
ISSN:1550-6606
DOI:10.4049/jimmunol.1101612

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