Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication
It was recently reported that inhibitory molecules such as programmed death-1 (PD-1) were upregulated on CD8+ T cells during acute Friend retrovirus infection and that the cells were prematurely exhausted and dysfunctional in vitro. The current study confirms that most activated CD8+ T cells upregul...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 01, 2011
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| In: |
The journal of immunology
Year: 2011, Jahrgang: 187, Heft: 7, Pages: 3730-3737 |
| ISSN: | 1550-6606 |
| DOI: | 10.4049/jimmunol.1101612 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.1101612
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| Verfasserangaben: | Gennadiy Zelinskyy, Lara Myers, Kirsten K. Dietze, Kathrin Gibbert, Michael Roggendorf, Jia Liu, Mengji Lu, Anke R. Kraft, Volker Teichgräber, Kim J. Hasenkrug, and Ulf Dittmer |
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| 245 | 1 | 0 | |a Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication |c Gennadiy Zelinskyy, Lara Myers, Kirsten K. Dietze, Kathrin Gibbert, Michael Roggendorf, Jia Liu, Mengji Lu, Anke R. Kraft, Volker Teichgräber, Kim J. Hasenkrug, and Ulf Dittmer |
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| 520 | |a It was recently reported that inhibitory molecules such as programmed death-1 (PD-1) were upregulated on CD8+ T cells during acute Friend retrovirus infection and that the cells were prematurely exhausted and dysfunctional in vitro. The current study confirms that most activated CD8+ T cells upregulated expression of PD-1 during acute infection and revealed a dichotomy of function between PD-1hi and PD-1lo subsets. More PD-1lo cells produced antiviral cytokines such as IFN-γ and TNF-α, whereas more PD-1hi cells displayed characteristics of cytotoxic effectors such as production of granzymes and surface expression of CD107a. Importantly, CD8+ T cells mediated rapid in vivo cytotoxicity and were critical for control of acute Friend virus replication. Thus, direct ex vivo analyses and in vivo experiments revealed high CD8+ T cell functionality and indicate that PD-1 expression during acute infection is not a marker of T cell exhaustion. | ||
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