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Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication

It was recently reported that inhibitory molecules such as programmed death-1 (PD-1) were upregulated on CD8+ T cells during acute Friend retrovirus infection and that the cells were prematurely exhausted and dysfunctional in vitro. The current study confirms that most activated CD8+ T cells upregul...

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Hauptverfasser: Zelinskyy, Gennadiy (VerfasserIn) , Myers, Lara (VerfasserIn) , Dietze, Kirsten K. (VerfasserIn) , Gibbert, Kathrin (VerfasserIn) , Roggendorf, Michael (VerfasserIn) , Liu, Jia (VerfasserIn) , Lu, Mengji (VerfasserIn) , Kraft, Anke R. (VerfasserIn) , Teichgräber, Volker (VerfasserIn) , Hasenkrug, Kim J. (VerfasserIn) , Dittmer, Ulf (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: October 01, 2011
In: The journal of immunology
Year: 2011, Jahrgang: 187, Heft: 7, Pages: 3730-3737
ISSN:1550-6606
DOI:10.4049/jimmunol.1101612
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.1101612
Volltext
Verfasserangaben:Gennadiy Zelinskyy, Lara Myers, Kirsten K. Dietze, Kathrin Gibbert, Michael Roggendorf, Jia Liu, Mengji Lu, Anke R. Kraft, Volker Teichgräber, Kim J. Hasenkrug, and Ulf Dittmer
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Zusammenfassung:It was recently reported that inhibitory molecules such as programmed death-1 (PD-1) were upregulated on CD8+ T cells during acute Friend retrovirus infection and that the cells were prematurely exhausted and dysfunctional in vitro. The current study confirms that most activated CD8+ T cells upregulated expression of PD-1 during acute infection and revealed a dichotomy of function between PD-1hi and PD-1lo subsets. More PD-1lo cells produced antiviral cytokines such as IFN-γ and TNF-α, whereas more PD-1hi cells displayed characteristics of cytotoxic effectors such as production of granzymes and surface expression of CD107a. Importantly, CD8+ T cells mediated rapid in vivo cytotoxicity and were critical for control of acute Friend virus replication. Thus, direct ex vivo analyses and in vivo experiments revealed high CD8+ T cell functionality and indicate that PD-1 expression during acute infection is not a marker of T cell exhaustion.
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Beschreibung:Online Resource
ISSN:1550-6606
DOI:10.4049/jimmunol.1101612

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