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Nalmefene attenuates neural alcohol cue-reactivity in the ventral striatum and subjective alcohol craving in patients with alcohol use disorder

Alcohol use disorder is a common and devastating mental illness for which satisfactory treatments are still lacking. Nalmefene, as an opioid receptor modulator, could pharmacologically support the reduction of drinking by reducing the (anticipated) rewarding effects of alcohol and expanding the rang...

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Bibliographic Details
Main Authors: Karl, Damian (Author) , Bumb, Jan Malte (Author) , Bach, Patrick (Author) , Dinter, Christina (Author) , Koopmann, Anne (Author) , Hermann, Derik (Author) , Mann, Karl (Author) , Kiefer, Falk (Author) , Vollstädt-Klein, Sabine (Author)
Format: Article (Journal)
Language:English
Published: 12 April 2021
In: Psychopharmacology
Year: 2021, Volume: 238, Issue: 8, Pages: 2179-2189
ISSN:1432-2072
DOI:10.1007/s00213-021-05842-7
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00213-021-05842-7
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Author Notes:Damian Karl, J. Malte Bumb, Patrick Bach, Christina Dinter, Anne Koopmann, Derik Hermann, Karl Mann, Falk Kiefer, Sabine Vollstädt-Klein
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Summary:Alcohol use disorder is a common and devastating mental illness for which satisfactory treatments are still lacking. Nalmefene, as an opioid receptor modulator, could pharmacologically support the reduction of drinking by reducing the (anticipated) rewarding effects of alcohol and expanding the range of treatment options. It has been hypothesized that nalmefene acts via an indirect modulation of the mesolimbic reward system. So far, only a few imaging findings on the neuronal response to nalmefene are available.
Item Description:Gesehen am 04.01.2023
Physical Description:Online Resource
ISSN:1432-2072
DOI:10.1007/s00213-021-05842-7

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