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Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing sarcoma (EwS) and alveolar rhabdomyosarcoma (ARMS). Despite their exquisite specificity, these driver oncogenes have been considered largely undruggable du...

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Main Authors: Hölting, Tilman (Author) , Cidre-Aranaz, Florencia (Author) , Matzek, Dana (Author) , Popper, Bastian (Author) , Jacobi, Severin J. (Author) , Funk, Cornelius M. (Author) , Geyer, Florian H. (Author) , Li, Jing (Author) , Piseddu, Ignazio (Author) , Cadilha, Bruno L. (Author) , Ledderose, Stephan (Author) , Zwilling, Jennifer (Author) , Ohmura, Shunya (Author) , Anz, David (Author) , Künkele, Annette (Author) , Klauschen, Frederick (Author) , Grünewald, Thomas G. P. (Author) , Knott, Maximilian M. L. (Author)
Format: Article (Journal)
Language:English
Published: 13 October 2022
In: Molecular cancer
Year: 2022, Volume: 21, Pages: 1-11
ISSN:1476-4598
DOI:10.1186/s12943-022-01641-6
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12943-022-01641-6
Verlag, lizenzpflichtig, Volltext: https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-022-01641-6
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Author Notes:Tilman L.B. Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J. Jacobi, Cornelius M. Funk, Florian H. Geyer, Jing Li, Ignazio Piseddu, Bruno L. Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G.P. Grünewald and Maximilian M.L. Knott
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Summary:Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing sarcoma (EwS) and alveolar rhabdomyosarcoma (ARMS). Despite their exquisite specificity, these driver oncogenes have been considered largely undruggable due to their lack of enzymatic activity.
Item Description:Gesehen am 10.01.2023
Physical Description:Online Resource
ISSN:1476-4598
DOI:10.1186/s12943-022-01641-6

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