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Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system

Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. Patient-derived organoids have demonstrated great potential as tumor avatars for drug response prediction in PDAC, yet they disregard the influen...

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Main Authors: Schuth, Sebastian (Author) , Le Blanc, Solange (Author) , Krieger, Teresa G. (Author) , Jabs, Julia (Author) , Schenk, Miriam (Author) , Giese, Nathalia (Author) , Büchler, Markus W. (Author) , Eils, Roland (Author) , Conrad, Christian (Author) , Strobel, Oliver (Author)
Format: Article (Journal)
Language:English
Published: 22 October 2022
In: Journal of experimental & clinical cancer research
Year: 2022, Volume: 41, Pages: 1-14
ISSN:1756-9966
DOI:10.1186/s13046-022-02519-7
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s13046-022-02519-7
Verlag, kostenfrei, Volltext: https://jeccr.biomedcentral.com/articles/10.1186/s13046-022-02519-7
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Author Notes:Sebastian Schuth, Solange Le Blanc, Teresa G. Krieger, Julia Jabs, Miriam Schenk, Nathalia A. Giese, Markus W. Büchler, Roland Eils, Christian Conrad and Oliver Strobel
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Summary:Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. Patient-derived organoids have demonstrated great potential as tumor avatars for drug response prediction in PDAC, yet they disregard the influence of stromal components on chemosensitivity.
Item Description:Gesehen am 10.01.2023
Physical Description:Online Resource
ISSN:1756-9966
DOI:10.1186/s13046-022-02519-7

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