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Metabolic heterogeneity of brain tumor cells of proneural and mesenchymal origin

Brain-tumor-initiating cells (BTICs) of proneural and mesenchymal origin contribute to the highly malignant phenotype of glioblastoma (GB) and resistance to current therapies. BTICs of different subtypes were challenged with oxidative phosphorylation (OXPHOS) inhibition with metformin to assess the...

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Autori principali: Seliger, Corinna (Autore) , Meyer, Anne-Louise (Autore) , Leidgens, Verena (Autore) , Rauer, Lisa (Autore) , Möckel, Sylvia (Autore) , Jachnik, Birgit (Autore) , Proske, Judith (Autore) , Dettmer-Wilde, Katja (Autore) , Rothhammer-Hampl, Tanja (Autore) , Kaulen, Leon D. (Autore) , Riemenschneider, Markus J. (Autore) , Oefner, Peter J. (Autore) , Kreutz, Marina (Autore) , Schmidt, Nils Ole (Autore) , Merrill, Marsha (Autore) , Uhl, Martin (Autore) , Renner, Kathrin (Autore) , Vollmann-Zwerenz, Arabel (Autore) , Proescholdt, Martin (Autore) , Hau, Peter (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 1 October 2022
In: International journal of molecular sciences
Year: 2022, Volume: 23, Fascicolo: 19, Pages: 1-20
ISSN:1422-0067
DOI:10.3390/ijms231911629
Accesso online:Verlag, Volltext: https://doi.org/10.3390/ijms231911629
Verlag, Volltext: https://www.mdpi.com/1422-0067/23/19/11629
Testo
Note sull'autore:Corinna Seliger, Anne-Louise Meyer, Verena Leidgens, Lisa Rauer, Sylvia Moeckel, Birgit Jachnik, Judith Proske, Katja Dettmer, Tanja Rothhammer-Hampl, Leon D. Kaulen, Markus J. Riemenschneider, Peter J. Oefner, Marina Kreutz, Nils-Ole Schmidt, Marsha Merrill, Martin Uhl, Kathrin Renner, Arabel Vollmann-Zwerenz, Martin Proescholdt and Peter Hau
Descrizione
Riassunto:Brain-tumor-initiating cells (BTICs) of proneural and mesenchymal origin contribute to the highly malignant phenotype of glioblastoma (GB) and resistance to current therapies. BTICs of different subtypes were challenged with oxidative phosphorylation (OXPHOS) inhibition with metformin to assess the differential effects of metabolic intervention on key resistance features. Whereas mesenchymal BTICs varied according to their invasiveness, they were in general more glycolytic and less responsive to metformin. Proneural BTICs were less invasive, catabolized glucose more via the pentose phosphate pathway, and responded better to metformin. Targeting glycolysis may be a promising approach to inhibit tumor cells of mesenchymal origin, whereas proneural cells are more responsive to OXPHOS inhibition. Future clinical trials exploring metabolic interventions should account for metabolic heterogeneity of brain tumors.
Descrizione del documento:Gesehen am 11.01.2023
Descrizione fisica:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms231911629

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