Elevated platelet-leukocyte complexes are associated with, but dispensable for myocardial ischemia-reperfusion injury

P-selectin is an activatable adhesion molecule on platelets promoting platelet aggregation, and platelet-leukocyte complex (PLC) formation. Increased numbers of PLC are circulating in the blood of patients shortly after acute myocardial infarction and predict adverse outcomes. These correlations led...

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Main Authors: Starz, Christopher (Author) , Härdtner, Carmen (Author) , Mauler, Maximilian (Author) , Dufner, Bianca (Author) , Hoppe, Natalie (Author) , Krebs, Katja (Author) , Ehlert, Carolin Anna (Author) , Merz, Julian (Author) , Heidt, Timo (Author) , Stachon, Peter (Author) , Wolf, Dennis (Author) , Bode, Christoph (Author) , Zur Mühlen, Constantin von (Author) , Rottbauer, Wolfgang (Author) , Gawaz, Meinrad Paul (Author) , Dürschmied, Daniel (Author) , Leuschner, Florian (Author) , Borst, Oliver (Author) , Westermann, Dirk (Author) , Hilgendorf, Ingo (Author)
Format: Article (Journal)
Language:English
Published: 16 November 2022
In: Basic research in cardiology
Year: 2022, Volume: 117, Pages: 1-14
ISSN:1435-1803
DOI:10.1007/s00395-022-00970-3
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00395-022-00970-3
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Author Notes:Christopher Starz, Carmen Härdtner, Maximilian Mauler, Bianca Dufner, Natalie Hoppe, Katja Krebs, Carolin Anna Ehlert, Julian Merz, Timo Heidt, Peter Stachon, Dennis Wolf, Christoph Bode, Constantin von zur Muehlen, Wolfgang Rottbauer, Meinrad Gawaz, Daniel Duerschmied, Florian Leuschner, Oliver Borst, Dirk Westermann, Ingo Hilgendorf
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Summary:P-selectin is an activatable adhesion molecule on platelets promoting platelet aggregation, and platelet-leukocyte complex (PLC) formation. Increased numbers of PLC are circulating in the blood of patients shortly after acute myocardial infarction and predict adverse outcomes. These correlations led to speculations about whether PLC may represent novel therapeutic targets. We therefore set out to elucidate the pathomechanistic relevance of PLC in myocardial ischemia and reperfusion injury.
Item Description:Gesehen am 11.01.2023
Physical Description:Online Resource
ISSN:1435-1803
DOI:10.1007/s00395-022-00970-3