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Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Current guidelines for HCC management recommend surveillance of high-risk patients every 6 mo using ultrasonography. Serum biomarkers, like alpha-fetoprotein (AFP), protein induced by vitamin K absence/antagonist-II (PIV...

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Main Authors: Malik, Juliane (Author) , Klammer, Martin (Author) , Rolny, Vinzent (Author) , Chan, Henry Lik-Yuen (Author) , Piratvisuth, Teerha (Author) , Tanwandee, Tawesak (Author) , Thongsawat, Satawat (Author) , Sukeepaisarnjaroen, Wattana (Author) , Esteban, Juan Ignacio (Author) , Bes, Marta (Author) , Köhler, Bruno Christian (Author) , Lange, Magdalena Swiatek-de (Author)
Format: Article (Journal)
Language:English
Published: August 7, 2022
In: World journal of gastroenterology
Year: 2022, Volume: 28, Issue: 29, Pages: 3917-3933
ISSN:2219-2840
DOI:10.3748/wjg.v28.i29.3917
Online Access:Verlag, Volltext: https://doi.org/10.3748/wjg.v28.i29.3917
Verlag, Volltext: https://www.wjgnet.com/1007-9327/full/v28/i29/3917.htm
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Author Notes:Juliane Malik, Martin Klammer, Vinzent Rolny, Henry Lik-Yuen Chan, Teerha Piratvisuth, Tawesak Tanwandee, Satawat Thongsawat, Wattana Sukeepaisarnjaroen, Juan Ignacio Esteban, Marta Bes, Bruno Köhler, Magdalena Swiatek-de Lange
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Summary:Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Current guidelines for HCC management recommend surveillance of high-risk patients every 6 mo using ultrasonography. Serum biomarkers, like alpha-fetoprotein (AFP), protein induced by vitamin K absence/antagonist-II (PIVKA-II) and lectin-reactive AFP, show suboptimal performance for detection of HCC, which is crucial for successful resection or treatment. Thus, there is a significant need for new biomarkers to aid early diagnosis of HCC. Studies have shown that the expression level of human microRNAs (miRNAs), a small, non-coding RNA species released into the blood, can serve as an early marker for various diseases, including HCC.
Item Description:Gesehen am 12.01.2023
Physical Description:Online Resource
ISSN:2219-2840
DOI:10.3748/wjg.v28.i29.3917

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