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Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Current guidelines for HCC management recommend surveillance of high-risk patients every 6 mo using ultrasonography. Serum biomarkers, like alpha-fetoprotein (AFP), protein induced by vitamin K absence/antagonist-II (PIV...

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Hauptverfasser: Malik, Juliane (VerfasserIn) , Klammer, Martin (VerfasserIn) , Rolny, Vinzent (VerfasserIn) , Chan, Henry Lik-Yuen (VerfasserIn) , Piratvisuth, Teerha (VerfasserIn) , Tanwandee, Tawesak (VerfasserIn) , Thongsawat, Satawat (VerfasserIn) , Sukeepaisarnjaroen, Wattana (VerfasserIn) , Esteban, Juan Ignacio (VerfasserIn) , Bes, Marta (VerfasserIn) , Köhler, Bruno Christian (VerfasserIn) , Lange, Magdalena Swiatek-de (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: August 7, 2022
In: World journal of gastroenterology
Year: 2022, Jahrgang: 28, Heft: 29, Pages: 3917-3933
ISSN:2219-2840
DOI:10.3748/wjg.v28.i29.3917
Online-Zugang:Verlag, Volltext: https://doi.org/10.3748/wjg.v28.i29.3917
Verlag, Volltext: https://www.wjgnet.com/1007-9327/full/v28/i29/3917.htm
Volltext
Verfasserangaben:Juliane Malik, Martin Klammer, Vinzent Rolny, Henry Lik-Yuen Chan, Teerha Piratvisuth, Tawesak Tanwandee, Satawat Thongsawat, Wattana Sukeepaisarnjaroen, Juan Ignacio Esteban, Marta Bes, Bruno Köhler, Magdalena Swiatek-de Lange
Beschreibung
Zusammenfassung:Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Current guidelines for HCC management recommend surveillance of high-risk patients every 6 mo using ultrasonography. Serum biomarkers, like alpha-fetoprotein (AFP), protein induced by vitamin K absence/antagonist-II (PIVKA-II) and lectin-reactive AFP, show suboptimal performance for detection of HCC, which is crucial for successful resection or treatment. Thus, there is a significant need for new biomarkers to aid early diagnosis of HCC. Studies have shown that the expression level of human microRNAs (miRNAs), a small, non-coding RNA species released into the blood, can serve as an early marker for various diseases, including HCC.
Beschreibung:Gesehen am 12.01.2023
Beschreibung:Online Resource
ISSN:2219-2840
DOI:10.3748/wjg.v28.i29.3917

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