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Shorter versus longer corticosteroid duration and recurrent immune checkpoint inhibitor-associated AKI

Corticosteroids are the mainstay of treatment for immune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI), but the optimal duration of therapy has not been established. Prolonged use of corticosteroids can cause numerous adverse effects and may decrease progression-free survival among...

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Main Authors: Gupta, Shruti (Author) , Garcia-Carro, Clara (Author) , Prosek, Jason M. (Author) , Glezerman, Ilya (Author) , Herrmann, Sandra M. (Author) , Garcia, Pablo (Author) , Abudayyeh, Ala (Author) , Lumlertgul, Nuttha (Author) , Malik, A. Bilal (Author) , Loew, Sebastian (Author) , Beckerman, Pazit (Author) , Renaghan, Amanda D. (Author) , Carlos, Christopher A. (Author) , Rashidi, Arash (Author) , Mithani, Zain (Author) , Deshpande, Priya (Author) , Rangarajan, Sunil (Author) , Shah, Chintan V. (Author) , Seigneux, Sophie De (Author) , Campedel, Luca (Author) , Kitchlu, Abhijat (Author) , Shin, Daniel Sanghoon (Author) , Coppock, Gaia (Author) , Ortiz-Melo, David I. (Author) , Sprangers, Ben (Author) , Aggarwal, Vikram (Author) , Gente, Karolina (Author) , Wanchoo, Rimda (Author) , Murakami, Naoka (Author) , Cortazar, Frank B. (Author) , Reynolds, Kerry L. (Author) , Sise, Meghan E. (Author) , Soler, Maria Jose (Author) , Leaf, David E. (Author)
Format: Article (Journal)
Language:English
Published: September 22, 2022
In: Journal for ImmunoTherapy of Cancer
Year: 2022, Volume: 10, Issue: 9, Pages: 1-7
ISSN:2051-1426
DOI:10.1136/jitc-2022-005646
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/jitc-2022-005646
Verlag, lizenzpflichtig, Volltext: https://jitc.bmj.com/content/10/9/e005646
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Author Notes:Shruti Gupta, Clara Garcia-Carro, Jason M Prosek, Ilya Glezerman, Sandra M Herrmann, Pablo Garcia, Ala Abudayyeh, Nuttha Lumlertgul, A Bilal Malik, Sebastian Loew, Pazit Beckerman, Amanda D Renaghan, Christopher A Carlos, Arash Rashidi, Zain Mithani, Priya Deshpande, Sunil Rangarajan, Chintan V Shah, Sophie De Seigneux, Luca Campedel, Abhijat Kitchlu, Daniel Sanghoon Shin, Gaia Coppock, David I Ortiz-Melo, Ben Sprangers, Vikram Aggarwal, Karolina Benesova, Rimda Wanchoo, Naoka Murakami, Frank B Cortazar, Kerry L Reynolds, Meghan E Sise, Maria Jose Soler, David E Leaf, ICPi-AKI Consortium
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Summary:Corticosteroids are the mainstay of treatment for immune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI), but the optimal duration of therapy has not been established. Prolonged use of corticosteroids can cause numerous adverse effects and may decrease progression-free survival among patients treated with ICPis. We sought to determine whether a shorter duration of corticosteroids was equally efficacious and safe as compared with a longer duration.
Item Description:Gesehen am 13.01.2023
Physical Description:Online Resource
ISSN:2051-1426
DOI:10.1136/jitc-2022-005646

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