Therapeutic reference range for aripiprazole in schizophrenia revised: a systematic review and metaanalysis

While one of the basic axioms of pharmacology postulates that there is a relationship between the concentration and effects of a drug, the value of measuring blood levels is questioned by many clinicians. This is due to the often-missing validation of therapeutic reference ranges.

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Main Authors: Hart, Xenia Marlene (Author) , Hiemke, Christoph (Author) , Eichentopf, Luzie (Author) , Lense, Xenija M. (Author) , Clement, Hans-Willi (Author) , Conca, Andreas (Author) , Faltraco, Frank (Author) , Florio, Vincenzo (Author) , Grüner, Jessica (Author) , Havemann-Reinecke, Ursula (Author) , Molden, Espen (Author) , Paulzen, Michael (Author) , Schoretsanitēs, Geōrgios (Author) , Riemer, Thomas Günther (Author) , Gründer, Gerhard (Author)
Format: Article (Journal)
Language:English
Published: 05 October 2022
In: Psychopharmacology
Year: 2022, Volume: 239, Issue: 11, Pages: 3377-3391
ISSN:1432-2072
DOI:10.1007/s00213-022-06233-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00213-022-06233-2
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Author Notes:Xenia M. Hart, Christoph Hiemke, Luzie Eichentopf, Xenija M. Lense, Hans Willi Clement, Andreas Conca, Frank Faltraco, Vincenzo Florio, Jessica Grüner, Ursula Havemann-Reinecke, Espen Molden, Michael Paulzen, Georgios Schoretsanitis, Thomas G. Riemer, Gerhard Gründer
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Summary:While one of the basic axioms of pharmacology postulates that there is a relationship between the concentration and effects of a drug, the value of measuring blood levels is questioned by many clinicians. This is due to the often-missing validation of therapeutic reference ranges.
Item Description:Gesehen am 18.01.2023
Physical Description:Online Resource
ISSN:1432-2072
DOI:10.1007/s00213-022-06233-2