Cover Image

In vitro and in silico analysis of new n-butyl and isobutyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives against trypanosoma cruzi as Trypanothione reductase inhibitors

American trypanosomiasis is a worldwide health problem that requires attention due to ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives against trypomastigotes of the Trypanosoma cruzi strains NINOA and INC-5. An in silico analysis...

Full description

Saved in:
Bibliographic Details
Main Authors: González-González, Alonzo (Author) , Sánchez-Sánchez, Oscar (Author) , Krauth-Siegel, Renate (Author) , Bolognesi, Maria Laura (Author) , Gớmez-Escobedo, Rogelio (Author) , Nogueda-Torres, Benjamín (Author) , Vázquez-Jiménez, Lenci K. (Author) , Saavedra, Emma (Author) , Encalada, Rusely (Author) , Espinoza-Hicks, José Carlos (Author) , Paz-González, Alma D. (Author) , Rivera, Gildardo (Author)
Format: Article (Journal)
Language:English
Published: 1 November 2022
In: International journal of molecular sciences
Year: 2022, Volume: 23, Issue: 21, Pages: 1-18
ISSN:1422-0067
DOI:10.3390/ijms232113315
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms232113315
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/23/21/13315
Get full text
Author Notes:Alonzo González-González, Oscar Sánchez-Sánchez, R. Luise Krauth-Siegel, Maria Laura Bolognesi, Rogelio Gớmez-Escobedo, Benjamín Nogueda-Torres, Lenci K. Vázquez-Jiménez, Emma Saavedra, Rusely Encalada, José Carlos Espinoza-Hicks, Alma D. Paz-González and Gildardo Rivera
Description
Summary:American trypanosomiasis is a worldwide health problem that requires attention due to ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives against trypomastigotes of the Trypanosoma cruzi strains NINOA and INC-5. An in silico analysis of the interactions of 1,4-di-N-oxide on the active site of trypanothione reductase (TR) and an enzyme inhibition study was carried out. The n-butyl series compound identified as T-150 had the best trypanocidal activity against T. cruzi trypomastigotes, with a 13% TR inhibition at 44 μM. The derivative T-147 behaved as a mixed inhibitor with Ki and Ki’ inhibition constants of 11.4 and 60.8 µM, respectively. This finding is comparable to the TR inhibitor mepacrine (Ki = 19 µM).
Item Description:Gesehen am 20.01.2023
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms232113315

Similar Items