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Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation

Using microarrays, we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD) and mental retardation. DNA sequencing of SHANK2 in 396 individuals with ASD, 184 individuals with mental retardation and 659 unaff...

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Main Authors: Berkel, Simone (Author) , Marshall, Christian R. (Author) , Weiß, Birgit (Author) , Howe, Jennifer (Author) , Röth, Ralph (Author) , Moog, Ute (Author) , Endris, Volker (Author) , Roberts, Wendy (Author) , Szatmari, Peter (Author) , Pinto, Dalila (Author) , Bonin, Michael (Author) , Riess, Angelika (Author) , Engels, Hartmut (Author) , Sprengel, Rolf (Author) , Scherer, Stephen W. (Author) , Rappold, Gudrun (Author)
Format: Article (Journal)
Language:English
Published: 16 May 2010
In: Nature genetics
Year: 2010, Volume: 42, Issue: 6, Pages: 489-491
ISSN:1546-1718
Online Access: Get full text
Author Notes:Simone Berkel, Christian R. Marshall, Birgit Weiss, Jennifer Howe, Ralph Roeth, Ute Moog, Volker Endris, Wendy Roberts, Peter Szatmari, Dalila Pinto, Michael Bonin, Angelika Riess, Hartmut Engels, Rolf Sprengel, Stephen W. Scherer & Gudrun A. Rappold
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Summary:Using microarrays, we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD) and mental retardation. DNA sequencing of SHANK2 in 396 individuals with ASD, 184 individuals with mental retardation and 659 unaffected individuals (controls) revealed additional variants that were specific to ASD and mental retardation cases, including a de novo nonsense mutation and seven rare inherited changes. Our findings further link common genes between ASD and intellectual disability.
Item Description:Gesehen am 20.01.2023
Physical Description:Online Resource
ISSN:1546-1718

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