Cover Image

TSC22D4 interacts with Akt1 to regulate glucose metabolism

Show other versions (2)

Maladaptive insulin signaling is a key feature in the pathogenesis of severe metabolic disorders, including obesity and diabetes. Enhancing insulin sensitivity represents a major goal in the treatment of patients affected by diabetes. Here, we identify transforming growth factor-β1 stimulated clone...

Full description

Saved in:
Bibliographic Details
Main Authors: Demir, Sevgican (Author) , Wolff, Gretchen (Author) , Wieder, Annika (Author) , Maida, Adriano (Author) , Bühler, Lea (Author) , Brune, Maik (Author) , Hautzinger, Oksana (Author) , Feuchtinger, Annette (Author) , Poth, Tanja (Author) , Szendrödi, Julia (Author) , Herzig, Stephan (Author) , Üstünel, Bilgen Ekim (Author)
Format: Article (Journal)
Language:English
Published: 21 October 2022
In: Science advances
Year: 2022, Volume: 8, Issue: 42, Pages: 1-15
ISSN:2375-2548
DOI:10.1126/sciadv.abo5555
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/sciadv.abo5555
Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/sciadv.abo5555
Get full text
Author Notes:Sevgican Demir, Gretchen Wolff, Annika Wieder, Adriano Maida, Lea Bühler, Maik Brune, Oksana Hautzinger, Annette Feuchtinger, Tanja Poth, Julia Szendroedi, Stephan Herzig, Bilgen Ekim Üstünel
Description
Summary:Maladaptive insulin signaling is a key feature in the pathogenesis of severe metabolic disorders, including obesity and diabetes. Enhancing insulin sensitivity represents a major goal in the treatment of patients affected by diabetes. Here, we identify transforming growth factor-β1 stimulated clone 22 D4 (TSC22D4) as a novel interaction partner for protein kinase B/Akt1, a critical mediator of insulin/phosphatidylinositol 3-kinase signaling pathway. While energy deprivation and oxidative stress promote the TSC22D4-Akt1 interaction, refeeding mice or exposing cells to glucose and insulin impairs this interaction, which relies on an intrinsically disordered region (D2 domain) within TSC22D4. Functionally, the interaction with TSC22D4 reduces basal phosphorylation of Akt and its downstream targets during starvation, thereby promoting insulin sensitivity. Genetic, liver-specific reconstitution experiments in mice demonstrate that the interaction between TSC22D4 and Akt1 improves glucose handling and insulin sensitivity. Overall, our findings postulate a model whereby TSC22D4 acts as an environmental sensor and interacts with Akt1 to regulate insulin signaling and glucose metabolism.
Item Description:Gesehen am 20.01.2023
Physical Description:Online Resource
ISSN:2375-2548
DOI:10.1126/sciadv.abo5555

Similar Items