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The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer

Here, we investigated the importance of PHD1-3 in an azoxymethane- (AOM-) and dextran sodium sulfate-induced (DSS-induced) mouse model of CAC. Moreover, to gain a deeper understanding of the specific role of PHD2 - the key oxygen sensor (25) - in the pathogenesis of CAC, we used transgenic mouse mod...

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Main Authors: Kennel, Kilian (Author) , Burmeister, Julius (Author) , Radhakrishnan, Praveen (Author) , Giese, Nathalia (Author) , Giese, Thomas (Author) , Salfenmoser, Martin (Author) , Gebhardt, Jasper M. (Author) , Strowitzki, Moritz (Author) , Taylor, Cormac T. (Author) , Wielockx, Ben (Author) , Schneider, Martin (Author) , Harnoß, Jonathan M. (Author)
Format: Article (Journal)
Language:English
Published: November 22, 2022
In: JCI insight
Year: 2022, Volume: 7, Issue: 22, Pages: 1-16
ISSN:2379-3708
DOI:10.1172/jci.insight.153337
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1172/jci.insight.153337
Verlag, lizenzpflichtig, Volltext: https://insight.jci.org/articles/view/153337
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Author Notes:Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, and Jonathan M. Harnoss
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Summary:Here, we investigated the importance of PHD1-3 in an azoxymethane- (AOM-) and dextran sodium sulfate-induced (DSS-induced) mouse model of CAC. Moreover, to gain a deeper understanding of the specific role of PHD2 - the key oxygen sensor (25) - in the pathogenesis of CAC, we used transgenic mouse models harboring a tissue-specific deletion of Phd2. We demonstrate that the 3 PHD isoenzymes have distinct, whether promoting (PHD1), diminishing (PHD2), or neutral (PHD3), effects on CAC growth in the AOM/DSS model.
Item Description:Gesehen am 24.01.2023
Physical Description:Online Resource
ISSN:2379-3708
DOI:10.1172/jci.insight.153337

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