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Here, we investigated the importance of PHD1-3 in an azoxymethane- (AOM-) and dextran sodium sulfate-induced (DSS-induced) mouse model of CAC. Moreover, to gain a deeper understanding of the specific role of PHD2 - the key oxygen sensor (25) - in the pathogenesis of CAC, we used transgenic mouse mod...

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Hauptverfasser: Kennel, Kilian (VerfasserIn) , Burmeister, Julius (VerfasserIn) , Radhakrishnan, Praveen (VerfasserIn) , Giese, Nathalia (VerfasserIn) , Giese, Thomas (VerfasserIn) , Salfenmoser, Martin (VerfasserIn) , Gebhardt, Jasper M. (VerfasserIn) , Strowitzki, Moritz (VerfasserIn) , Taylor, Cormac T. (VerfasserIn) , Wielockx, Ben (VerfasserIn) , Schneider, Martin (VerfasserIn) , Harnoß, Jonathan M. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: November 22, 2022
In: JCI insight
Year: 2022, Jahrgang: 7, Heft: 22, Pages: 1-16
ISSN:2379-3708
DOI:10.1172/jci.insight.153337
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1172/jci.insight.153337
Verlag, lizenzpflichtig, Volltext: https://insight.jci.org/articles/view/153337
Volltext
Verfasserangaben:Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, and Jonathan M. Harnoss
Beschreibung
Zusammenfassung:Here, we investigated the importance of PHD1-3 in an azoxymethane- (AOM-) and dextran sodium sulfate-induced (DSS-induced) mouse model of CAC. Moreover, to gain a deeper understanding of the specific role of PHD2 - the key oxygen sensor (25) - in the pathogenesis of CAC, we used transgenic mouse models harboring a tissue-specific deletion of Phd2. We demonstrate that the 3 PHD isoenzymes have distinct, whether promoting (PHD1), diminishing (PHD2), or neutral (PHD3), effects on CAC growth in the AOM/DSS model.
Beschreibung:Gesehen am 24.01.2023
Beschreibung:Online Resource
ISSN:2379-3708
DOI:10.1172/jci.insight.153337

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