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Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Traumatic brain injury (TBI) is characterized by massive changes in neuronal excitation, from acute excitotoxicity to chronic hyper- or hypoexcitability. Nuclear calcium signaling pathways are involved in translating changes in synaptic inputs and neuronal activity into discrete transcriptional prog...

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Main Authors: Fröhlich, Albrecht (Author) , Olde Heuvel, Florian (Author) , Rehman, Rida (Author) , Krishnamurthy, Sruthi Sankari (Author) , Li, Shun (Author) , Li, Zhenghui (Author) , Bayer, David (Author) , Conquest, Alison (Author) , Hertle, Anna M. (Author) , Ludolph, Albert (Author) , Huber-Lang, Markus (Author) , Boeckers, Tobias (Author) , Knöll, Bernd (Author) , Morganti-Kossmann, Maria Cristina (Author) , Bading, Hilmar (Author) , Roselli, Francesco (Author)
Format: Article (Journal)
Language:English
Published: 19 November 2022
In: Journal of neuroinflammation
Year: 2022, Volume: 19, Pages: 1-25
ISSN:1742-2094
DOI:10.1186/s12974-022-02634-4
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12974-022-02634-4
Verlag, lizenzpflichtig, Volltext: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-022-02634-4
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Author Notes:Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading and Francesco Roselli
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Summary:Traumatic brain injury (TBI) is characterized by massive changes in neuronal excitation, from acute excitotoxicity to chronic hyper- or hypoexcitability. Nuclear calcium signaling pathways are involved in translating changes in synaptic inputs and neuronal activity into discrete transcriptional programs which not only affect neuronal survival and synaptic integrity, but also the crosstalk between neurons and glial cells. Here, we report the effects of blunting neuronal nuclear calcium signals in the context of TBI.
Item Description:Gesehen am 24.01.2023
Physical Description:Online Resource
ISSN:1742-2094
DOI:10.1186/s12974-022-02634-4

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