Ko-translationale Assemblierung von Proteinkomplexen: Methoden der Proteinforschung
The majority of cellular proteins exerts their biological activity as oligomeric complexes. The general view was that complexes form by random collision of folded subunits in the cytosol. Recent studies question this view by demonstrating that a surprisingly high number of complexes are formed durin...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | German |
| Published: |
24 November 2021
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| In: |
Biospektrum
Year: 2021, Volume: 27, Issue: 7, Pages: 723-726 |
| ISSN: | 1868-6249 |
| DOI: | 10.1007/s12268-021-1682-5 |
| Online Access: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1007/s12268-021-1682-5
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| Author Notes: | Kai Fenzl, Günter Kramer, Bernd Bukau |
| Summary: | The majority of cellular proteins exerts their biological activity as oligomeric complexes. The general view was that complexes form by random collision of folded subunits in the cytosol. Recent studies question this view by demonstrating that a surprisingly high number of complexes are formed during translation. Co-translational assembly occurs by interaction either of fully synthesized subunits with nascent partner subunits, or of two nascent polypeptides exposed by proximal ribosomes. |
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| Item Description: | Gesehen am 26.01.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1868-6249 |
| DOI: | 10.1007/s12268-021-1682-5 |