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Impaired in vitro growth response of plasma-treated cardiomyocytes predicts poor outcome in patients with transthyretin amyloidosis

Direct toxic effects of transthyretin amyloid in patient plasma upon cardiomyocytes are discussed. However, no data regarding the relevance of this putative effect for clinical outcome are available. In this monocentric prospective study, we analyzed cellular hypertrophy after phenylephrine stimulat...

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Main Authors: Hein, Selina (Author) , Furkel, Jennifer (Author) , Knoll, Maximilian (Author) , Siepen, Fabian aus dem (Author) , Schönland, Stefan (Author) , Hegenbart, Ute (Author) , Katus, Hugo (Author) , Kristen, Arnt (Author) , Konstandin, Mathias (Author)
Format: Article (Journal)
Language:English
Published: 22 January 2021
In: Clinical research in cardiology
Year: 2021, Volume: 110, Issue: 4, Pages: 579-590
ISSN:1861-0692
DOI:10.1007/s00392-020-01801-y
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1007/s00392-020-01801-y
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Author Notes:Selina Hein, Jennifer Furkel, Maximilian Knoll, Fabian aus dem Siepen, Stefan Schönland, Ute Hegenbart, Hugo A. Katus, Arnt V. Kristen, Mathias H. Konstandin
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Summary:Direct toxic effects of transthyretin amyloid in patient plasma upon cardiomyocytes are discussed. However, no data regarding the relevance of this putative effect for clinical outcome are available. In this monocentric prospective study, we analyzed cellular hypertrophy after phenylephrine stimulation in vitro in the presence of patient plasma and correlated the cellular growth response with phenotype and prognosis.
Item Description:Gesehen am 26.01.2023
Physical Description:Online Resource
ISSN:1861-0692
DOI:10.1007/s00392-020-01801-y

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