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Activated eosinophils predict longer progression-free survival under immune checkpoint inhibition in melanoma

Immune checkpoint inhibition (ICI) has yielded remarkable results in prolonging survival of metastatic melanoma patients but only a subset of individuals treated respond to therapy. Success of ICI treatment appears to depend on the number of tumor-infiltrating effector T-cells, which are known to be...

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Main Authors: Ammann, Nadine (Author) , Schwietzer, Yasmin F. (Author) , Meß, Christian (Author) , Stadler, Julia-Christina (Author) , Geidel, Glenn (Author) , Kött, Julian (Author) , Pantel, Klaus (Author) , Schneider, Stefan W. (Author) , Utikal, Jochen (Author) , Bauer, Alexander (Author) , Gebhardt, Christoffer (Author)
Format: Article (Journal)
Language:English
Published: 18 November 2022
In: Cancers
Year: 2022, Volume: 14, Issue: 22, Pages: 1-19
ISSN:2072-6694
DOI:10.3390/cancers14225676
Online Access:Resolving-System, Volltext: https://doi.org/10.3390/cancers14225676
Verlag, Volltext: https://www.mdpi.com/2072-6694/14/22/5676
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Author Notes:Nadine L. Ammann, Yasmin F. Schwietzer, Christian Mess, Julia-Christina Stadler, Glenn Geidel, Julian Kött, Klaus Pantel, Stefan W. Schneider, Jochen Utikal, Alexander T. Bauer and Christoffer Gebhardt
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Summary:Immune checkpoint inhibition (ICI) has yielded remarkable results in prolonging survival of metastatic melanoma patients but only a subset of individuals treated respond to therapy. Success of ICI treatment appears to depend on the number of tumor-infiltrating effector T-cells, which are known to be influenced by activated eosinophils. To verify the co-occurrence of activated eosinophils and T-cells in melanoma, immunofluorescence was performed in 285 primary or metastatic tumor tissue specimens from 118 patients. Moreover, eosinophil counts and activity markers such as eosinophil cationic protein (ECP) and eosinophil peroxidase (EPX) were measured in the serum before therapy start and before the 4th infusion of ICI in 45 metastatic unresected melanoma patients. We observed a positive correlation between increased tumor-infiltrating eosinophils and T-cells associated with delayed melanoma progression. High baseline levels of eosinophil count, serum ECP and EPX were linked to prolonged progression-free survival in metastatic melanoma. Our data provide first indications that activated eosinophils are related to the T-cell-inflamed tumor microenvironment and could be considered as potential future prognostic biomarkers in melanoma.
Item Description:Gesehen am 26.01.2023
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers14225676

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