Exploring biomarkers in routine diagnostics for the risk stratification of older patients in the Chest Pain Unit: a prospective cohort study
Objectives This study aims to estimate the association of the often, in daily clinical practice, used biological age-related biomarkers high-sensitivity troponin-T (hs-TnT), C reactive protein (CRP) and haemoglobin (Hb) with all-cause mortality for the purpose of older patient’s risk stratification...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2022
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| In: |
BMJ open
Year: 2022, Volume: 12, Issue: 12, Pages: 1-8 |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2021-056674 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1136/bmjopen-2021-056674 Verlag, kostenfrei, Volltext: https://bmjopen.bmj.com/content/12/12/e056674 
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| Author Notes: | Anna Lisa Kunz, Anton Schönstein, Philipp Bahrmann, Evangelos Giannitsis, Hans-Werner Wahl, Hugo A. Katus, Norbert Frey, Anke Bahrmann |
| Summary: | Objectives This study aims to estimate the association of the often, in daily clinical practice, used biological age-related biomarkers high-sensitivity troponin-T (hs-TnT), C reactive protein (CRP) and haemoglobin (Hb) with all-cause mortality for the purpose of older patient’s risk stratification in the emergency department (ED). - Design Exploratory, prospective cohort study with a follow-up at 2.5 years after recruitment started. For the predictors, data from the hospital files including the routinely applied biological age-related biomarkers hs-TnT, CRP and Hb were supplemented by a questionnaire. - Setting A cardiological ED, Chest Pain Unit, University Hospital Heidelberg, Germany. - Participants N=256 cardiological ED patients with a minimum age of 70 years and the capability to informed consent. - Primary outcome measures The primary outcome of this study was all-cause mortality which was assessed by requesting registry office information. - Results Among N=256 patients 63 died over the follow-up period. Positive results in each of the three biomarkers alone as well as the combination were associated with increased all-cause mortality at follow-up. The number of positive age-related biomarkers appeared to be strongly indicative of the risk of mortality, even when controlled for major confounders (age, sex, body mass index, creatinine clearance and comorbidity). - Conclusions In older ED patients, biomarkers explicitly related to biological ageing processes such as hs-TnT, CRP and Hb were to a certain degree independently of each other as well as combined associated with an increased risk of all-cause mortality. Thus, they may have the potential to be used to supplement the general risk stratification of older patients in the ED. Validation of the results in a large dataset is needed. |
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| Item Description: | Gesehen am 30.01.2023 |
| Physical Description: | Online Resource |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2021-056674 |