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Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues

Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results:nc886 methylation status is...

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Main Authors: Marttila, Saara (Author) , Tamminen, Hely (Author) , Rajić, Sonja (Author) , Mishra, Pashupati P (Author) , Lehtimäki, Terho (Author) , Raitakari, Olli (Author) , Kähönen, Mika (Author) , Kananen, Laura (Author) , Jylhävä, Juulia (Author) , Hägg, Sara (Author) , Delerue, Thomas (Author) , Peters, Annette (Author) , Waldenberger, Melanie (Author) , Kleber, Marcus E. (Author) , März, Winfried (Author) , Luoto, Riitta (Author) , Raitanen, Jani (Author) , Sillanpää, Elina (Author) , Laakkonen, Eija K (Author) , Heikkinen, Aino (Author) , Ollikainen, Miina (Author) , Raitoharju, Emma (Author)
Format: Article (Journal)
Language:English
Published: 5 Oct 2022
In: Epigenomics
Year: 2022, Volume: 14, Issue: 18, Pages: 1105-1124
ISSN:1750-192X
DOI:10.2217/epi-2022-0228
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2217/epi-2022-0228
Verlag, lizenzpflichtig, Volltext: https://www.futuremedicine.com/doi/10.2217/epi-2022-0228
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Author Notes:Saara Marttila, Hely Tamminen, Sonja Rajić, Pashupati P Mishra, Terho Lehtimäki, Olli Raitakari, Mika Kähönen, Laura Kananen, Juulia Jylhävä, Sara Hägg, Thomas Delerue, Annette Peters, Melanie Waldenberger, Marcus E Kleber, Winfried März, Riitta Luoto, Jani Raitanen, Elina Sillanpää, Eija K Laakkonen, Aino Heikkinen, Miina Ollikainen & Emma Raitoharju
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Summary:Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results:nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas ∼30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.
Item Description:Published online: 5 Oct 2022
Gesehen am 01.02.2023
Physical Description:Online Resource
ISSN:1750-192X
DOI:10.2217/epi-2022-0228

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