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Second messenger-mediated adjustment of bacterial swimming velocity

Bacteria swim by means of rotating flagella that are powered by ion influx through membrane-spanning motor complexes. Escherichia coli and related species harness a chemosensory and signal transduction machinery that governs the direction of flagellar rotation and allows them to navigate in chemical...

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Bibliographic Details
Main Authors: Böhm, Alex (Author) , Kaiser, Matthias (Author) , Li, Hui (Author) , Spangler, Christian (Author) , Kasper, Christoph Alexander (Author) , Ackermann, Martin (Author) , Kaever, Volkhard (Author) , Sourjik, Victor (Author) , Roth, Volker (Author) , Jenal, Urs (Author)
Format: Article (Journal)
Language:English
Published: 18 March 2010
In: Cell
Year: 2010, Volume: 141, Issue: 1, Pages: 107-116
ISSN:1097-4172
DOI:10.1016/j.cell.2010.01.018
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cell.2010.01.018
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S009286741000019X
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Author Notes:Alex Boehm, Matthias Kaiser, Hui Li, Christian Spangler, Christoph Alexander Kasper, Martin Ackermann, Volkhard Kaever, Victor Sourjik, Volker Roth, and Urs Jenal
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Summary:Bacteria swim by means of rotating flagella that are powered by ion influx through membrane-spanning motor complexes. Escherichia coli and related species harness a chemosensory and signal transduction machinery that governs the direction of flagellar rotation and allows them to navigate in chemical gradients. Here, we show that Escherichia coli can also fine-tune its swimming speed with the help of a molecular brake (YcgR) that, upon binding of the nucleotide second messenger cyclic di-GMP, interacts with the motor protein MotA to curb flagellar motor output. Swimming velocity is controlled by the synergistic action of at least five signaling proteins that adjust the cellular concentration of cyclic di-GMP. Activation of this network and the resulting deceleration coincide with nutrient depletion and might represent an adaptation to starvation. These experiments demonstrate that bacteria can modulate flagellar motor output and thus swimming velocity in response to environmental cues.
Item Description:Gesehen am 01.02.2023
Physical Description:Online Resource
ISSN:1097-4172
DOI:10.1016/j.cell.2010.01.018

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