Uremia aggravates left ventricular remodeling after myocardial infarction
Background: Renal failure is a well-established cardiovascular risk factor. We hypothesized that uremia negatively affects post-myocardial infarction (MI) remodeling and left ventricular (LV) function and examined the pathohistological correlations. Methods: Subtotally nephrectomized rats (SNX) and...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 19, 2010
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| In: |
American journal of nephrology
Year: 2010, Volume: 32, Issue: 1, Pages: 13-22 |
| ISSN: | 1421-9670 |
| DOI: | 10.1159/000313846 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000313846 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/313846 
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| Author Notes: | Ralf Dikow, Ulrike Schmidt, Lars P. Kihm, Matthias Schaier, Vedat Schwenger, Marie-Luise Gross, Hugo A. Katus, Martin Zeier, Stefan E. Hardt |
| Summary: | Background: Renal failure is a well-established cardiovascular risk factor. We hypothesized that uremia negatively affects post-myocardial infarction (MI) remodeling and left ventricular (LV) function and examined the pathohistological correlations. Methods: Subtotally nephrectomized rats (SNX) and controls with MI only (MIC) were examined 1, 4 and 8 weeks after MI. MI size, ejection fraction (EF), cardiac fibrosis, vascular density and cardiomyocyte density were studied. Results: The extension of MI was 0.08 ± 0.02 in SNX versus 0.06 ± 0.02 in MIC rats (p < 0.031). Prior to MI, EF was comparable in SNX and MIC (74 ± 3 vs. 72 ± 2%, n.s.). Despite a relatively small infarct size EF in SNX decreased to 58 ± 4% 1 week after infarction and progressively worsened to 51 ± 4% after 8 weeks. In MIC animals EF only slightly decreased 1 week after MI (70 ± 3%) and remained unchanged at follow-up. In SNX animals LV end-diastolic diameter continuously increased following MI throughout the study period indicating accelerated remodeling. Furthermore, accelerated myocardial fibrosis was already notable 1 week after MI in SNX animals and the volume density of capillaries and cardiomyocytes was significantly lower in SNX rats. Conclusion: MI in experimental uremia is associated with progressive impairment of LV function, LV dilatation and accelerated myocardial fibrosis. |
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| Item Description: | Gesehen am 02.02.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1421-9670 |
| DOI: | 10.1159/000313846 |