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Overall response to anti-IL-5/anti-IL5-Rα treatment in severe asthma does not depend on initial bronchodilator responsiveness

Positive bronchodilator responsiveness (BDR) (change in forced expiratory volume in 1 second [ΔFEV1] ≥ +200 mL and ≥ +12%) after inhalation of a short-acting beta-2 agonist has been an inclusion criterion in licensing trials of anti-interleukin 5/anti-interleukin 5 receptor alpha (anti-IL-5/anti-IL-...

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Main Authors: Mümmler, Carlo (Author) , Suhling, Hendrik (Author) , Walter, Julia (Author) , Kneidinger, Nikolaus (Author) , Buhl, Roland (Author) , Kayser, Moritz Z. (Author) , Drick, Nora (Author) , Behr, Jürgen (Author) , Welte, Tobias (Author) , Korn, Stephanie (Author) , Milger, Katrin (Author)
Format: Article (Journal)
Language:English
Published: 21 July 2022
In: The journal of allergy and clinical immunology. In practice
Year: 2022, Volume: 10, Issue: 12, Pages: 3174-3183
ISSN:2213-2201
DOI:10.1016/j.jaip.2022.07.007
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jaip.2022.07.007
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2213219822007061
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Author Notes:Carlo Mümmler, Hendrik Suhling, Julia Walter, Nikolaus Kneidinger, Roland Buhl, Moritz Z. Kayser, Nora Drick, Jürgen Behr, Tobias Welte, Stephanie Korn, Katrin Milger
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Summary:Positive bronchodilator responsiveness (BDR) (change in forced expiratory volume in 1 second [ΔFEV1] ≥ +200 mL and ≥ +12%) after inhalation of a short-acting beta-2 agonist has been an inclusion criterion in licensing trials of anti-interleukin 5/anti-interleukin 5 receptor alpha (anti-IL-5/anti-IL-5Rα) biologics in severe asthma. However, in clinical practice, patients with severe uncontrolled asthma frequently show a negative BDR. To investigate whether the response to anti-IL5/anti-IL5Rα therapies differs between patients with positive and negative BDR at baseline.
Item Description:Dateiversion vom 7. Dezember 2022
Gesehen am 07.02.2023
Physical Description:Online Resource
ISSN:2213-2201
DOI:10.1016/j.jaip.2022.07.007

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