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Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival

Chemotactic cytokines play a role in angiogenesis and attraction of immune cells. However, their contribution to tumor formation remains incompletely understood. In a previous transcriptome study, we identified a family of structurally related chemokines of the CXC-family to be specifically up-regul...

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Main Authors: Doll, Dietrich (Author) , Keller, Larissa (Author) , Maak, Matthias (Author) , Boulesteix, Anne-Laure (Author) , Siewert, Jörg R. (Author) , Holzmann, Bernhard (Author) , Janssen, Klaus-Peter (Author)
Format: Article (Journal)
Language:English
Published: 17 February 2010
In: International journal of colorectal disease
Year: 2010, Volume: 25, Issue: 5, Pages: 573-581
ISSN:1432-1262
DOI:10.1007/s00384-010-0901-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00384-010-0901-1
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Author Notes:Dietrich Doll, Larissa Keller, Matthias Maak, Anne-Laure Boulesteix, Jörg R. Siewert, Bernhard Holzmann, Klaus-Peter Janssen
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Summary:Chemotactic cytokines play a role in angiogenesis and attraction of immune cells. However, their contribution to tumor formation remains incompletely understood. In a previous transcriptome study, we identified a family of structurally related chemokines of the CXC-family to be specifically up-regulated in colorectal cancer. The aim of the present study was to investigate the regulation of their expression in colon cancer cells and to test the hypothesis that altered CXC-chemokine expression is related to critical clinical parameters, such as survival or metastasis formation.
Item Description:Gesehen am 16.02.2023
Physical Description:Online Resource
ISSN:1432-1262
DOI:10.1007/s00384-010-0901-1

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