Cover Image

Effects of distant metastasis and peripheral CA 15-3 on the induction of spontaneous T cell responses in breast cancer patients

Tumor-specific memory T cells are detectable in the bone marrow (BM) of a majority of breast cancer patients. In vitro they can be reactivated to IFN-γ producing, cytotoxic effector cells and reject autologous, xenotransplanted tumors in NOD/SCID mice after specific restimulation with autologous den...

Full description

Saved in:
Bibliographic Details
Main Authors: Domschke, Christoph (Author) , Schütz, Florian (Author) , Sommerfeldt, Nora (Author) , Rom, Joachim (Author) , Scharf, Alexander (Author) , Sohn, Christof (Author) , Schneeweiss, Andreas (Author) , Beckhove, Philipp (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Cancer immunology immunotherapy
Year: 2010, Volume: 59, Issue: 3, Pages: 479-486
ISSN:1432-0851
DOI:10.1007/s00262-009-0801-9
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00262-009-0801-9
Get full text
Author Notes:Christoph Domschke, Florian Schuetz, Nora Sommerfeldt, Joachim Rom, Alexander Scharf, Christof Sohn, Andreas Schneeweiss, Philipp Beckhove
Description
Summary:Tumor-specific memory T cells are detectable in the bone marrow (BM) of a majority of breast cancer patients. In vitro they can be reactivated to IFN-γ producing, cytotoxic effector cells and reject autologous, xenotransplanted tumors in NOD/SCID mice after specific restimulation with autologous dendritic cells (DC). In this study, we demonstrate the presence of specific tumor-reactive BM memory T cells in altogether 56 out of 129 primarily operated breast cancer patients by short-term IFN-γ EliSpot assays with unstimulated T cells and tumor antigen presenting, autologous DCs. We observed tumor-reactive BM memory T cells predominantly in patients with primarily metastatic disease (P = 0.011) or with increased concentrations of tumor marker CA 15-3 in the peripheral blood (P = 0.004), respectively. Memory T cell reactivity against HLA-A*0201-restricted peptides from the tumor-associated antigens MUC1, Hpa16-24 and Hpa183-191 was also detected particularly in patients with elevated peripheral CA 15-3 concentrations (P < 0.05). Altogether these data indicate that the systemic presence of tumor-derived antigens promotes an induction of tumor-specific cellular immune responses in the human BM.
Item Description:Published online: 2 December 2009
Gesehen am 16.02.2023
Physical Description:Online Resource
ISSN:1432-0851
DOI:10.1007/s00262-009-0801-9

Similar Items