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Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling

SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative factors underlying differences in disease severity and to develop optimal vaccines again...

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Main Authors: Schreibing, Felix (Author) , Hannani, Monica T. (Author) , Kim, Hyojin (Author) , Nagai, James S. (Author) , Ticconi, Fabio (Author) , Fewings, Eleanor (Author) , Bleckwehl, Tore (Author) , Begemann, Matthias (Author) , Torow, Natalia (Author) , Kuppe, Christoph (Author) , Kurth, Ingo (Author) , Kranz, Jennifer (Author) , Frank, Dario (Author) , Anslinger, Teresa M. (Author) , Ziegler, Patrick (Author) , Kraus, Thomas (Author) , Enczmann, Jürgen (Author) , Balz, Vera (Author) , Windhofer, Frank (Author) , Balfanz, Paul (Author) , Kurts, Christian (Author) , Marx, Gernot (Author) , Marx, Nikolaus (Author) , Dreher, Michael (Author) , Schneider, Rebekka K. (Author) , Sáez Rodríguez, Julio (Author) , Costa, Ivan (Author) , Hayat, Sikander (Author) , Kramann, Rafael (Author)
Format: Article (Journal)
Language:English
Published: 16 December 2022
In: Frontiers in immunology
Year: 2022, Volume: 13, Pages: 1-23
ISSN:1664-3224
DOI:10.3389/fimmu.2022.1066176
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3389/fimmu.2022.1066176
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1066176
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Author Notes:Felix Schreibing, Monica T. Hannani, Hyojin Kim, James S. Nagai, Fabio Ticconi, Eleanor Fewings, Tore Bleckwehl, Matthias Begemann, Natalia Torow, Christoph Kuppe, Ingo Kurth, Jennifer Kranz, Dario Frank, Teresa M. Anslinger, Patrick Ziegler, Thomas Kraus, Jürgen Enczmann, Vera Balz, Frank Windhofer, Paul Balfanz, Christian Kurts, Gernot Marx, Nikolaus Marx, Michael Dreher, Rebekka K. Schneider, Julio Saez-Rodriguez, Ivan Costa, Sikander Hayat and Rafael Kramann
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Summary:SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative factors underlying differences in disease severity and to develop optimal vaccines against new SARS-CoV-2 variants.
Item Description:Gesehen am 21.02.2023
Physical Description:Online Resource
ISSN:1664-3224
DOI:10.3389/fimmu.2022.1066176

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