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African-specific polymorphisms in Plasmodium falciparum serine repeat antigen 5 in Uganda and Burkina Faso clinical samples do not interfere with antibody response to BK-SE36 vaccination

BK-SE36, based on Plasmodium falciparum serine repeat antigen 5 (SERA5), is a blood-stage malaria vaccine candidate currently being evaluated in clinical trials. Phase 1 trials in Uganda and Burkina Faso have demonstrated promising safety and immunogenicity profiles. However, the genetic diversity o...

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Main Authors: Arisue, Nobuko (Author) , Palacpac, Nirianne Marie Q. (Author) , Ntege, Edward H. (Author) , Yeka, Adoke (Author) , Balikagala, Betty (Author) , Kanoi, Bernard N. (Author) , Bougouma, Edith Christiane (Author) , Tiono, Alfred B. (Author) , Nebie, Issa (Author) , Diarra, Amidou (Author) , Houard, Sophie (Author) , D'Alessio, Flavia (Author) , Leroy, Odile (Author) , Sirima, Sodiomon B. (Author) , Egwang, Thomas G. (Author) , Horii, Toshihiro (Author)
Format: Article (Journal)
Language:English
Published: 16 December 2022
In: Frontiers in Cellular and Infection Microbiology
Year: 2022, Volume: 12, Pages: 1-15
ISSN:2235-2988
DOI:10.3389/fcimb.2022.1058081
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fcimb.2022.1058081
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fcimb.2022.1058081
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Author Notes:Nobuko Arisue, Nirianne Marie Q. Palacpac, Edward H. Ntege, Adoke Yeka, Betty Balikagala, Bernard N. Kanoi, Edith Christiane Bougouma, Alfred B. Tiono, Issa Nebie, Amidou Diarra, Sophie Houard, Flavia D’Alessio, Odile Leroy, Sodiomon B. Sirima, Thomas G. Egwang and Toshihiro Horii
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Summary:BK-SE36, based on Plasmodium falciparum serine repeat antigen 5 (SERA5), is a blood-stage malaria vaccine candidate currently being evaluated in clinical trials. Phase 1 trials in Uganda and Burkina Faso have demonstrated promising safety and immunogenicity profiles. However, the genetic diversity of sera5 in Africa and the role of allele/variant-specific immunity remain a major concern. Here, sequence analyses were done on 226 strains collected from the two clinical trial/follow-up studies and 88 strains from two cross-sectional studies in Africa. Compared to other highly polymorphic vaccine candidate antigens, polymorphisms in sera5 were largely confined to the repeat regions of the gene. Results also confirmed a SERA5 consensus sequence with African-specific polymorphisms.
Item Description:Gesehen am 21.02.2023
Physical Description:Online Resource
ISSN:2235-2988
DOI:10.3389/fcimb.2022.1058081

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