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African-specific polymorphisms in Plasmodium falciparum serine repeat antigen 5 in Uganda and Burkina Faso clinical samples do not interfere with antibody response to BK-SE36 vaccination

BK-SE36, based on Plasmodium falciparum serine repeat antigen 5 (SERA5), is a blood-stage malaria vaccine candidate currently being evaluated in clinical trials. Phase 1 trials in Uganda and Burkina Faso have demonstrated promising safety and immunogenicity profiles. However, the genetic diversity o...

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Main Authors: Arisue, Nobuko (Author) , Palacpac, Nirianne Marie Q. (Author) , Ntege, Edward H. (Author) , Yeka, Adoke (Author) , Balikagala, Betty (Author) , Kanoi, Bernard N. (Author) , Bougouma, Edith Christiane (Author) , Tiono, Alfred B. (Author) , Nebie, Issa (Author) , Diarra, Amidou (Author) , Houard, Sophie (Author) , D'Alessio, Flavia (Author) , Leroy, Odile (Author) , Sirima, Sodiomon B. (Author) , Egwang, Thomas G. (Author) , Horii, Toshihiro (Author)
Format: Article (Journal)
Language:English
Published: 16 December 2022
In: Frontiers in Cellular and Infection Microbiology
Year: 2022, Volume: 12, Pages: 1-15
ISSN:2235-2988
DOI:10.3389/fcimb.2022.1058081
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fcimb.2022.1058081
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fcimb.2022.1058081
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Author Notes:Nobuko Arisue, Nirianne Marie Q. Palacpac, Edward H. Ntege, Adoke Yeka, Betty Balikagala, Bernard N. Kanoi, Edith Christiane Bougouma, Alfred B. Tiono, Issa Nebie, Amidou Diarra, Sophie Houard, Flavia D’Alessio, Odile Leroy, Sodiomon B. Sirima, Thomas G. Egwang and Toshihiro Horii

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