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PNPLA3(I148M) inhibits lipolysis by perilipin-5-dependent competition with ATGL

The single nucleotide polymorphism I148M of the lipase patatin-like phospholipase domain containing 3 (PNPLA3) is associated with an unfavorable prognosis in alcoholic and non-alcoholic steatohepatitis (ASH, NASH), with progression to liver cirrhosis and development of hepatocellular carcinoma. In t...

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Main Authors: Witzel, Hagen Roland (Author) , Schwittai, Inga Maria Gertrud (Author) , Hartmann, Nils (Author) , Mueller, Sebastian (Author) , Schattenberg, Jörn Markus (Author) , Gong, Xue-Min (Author) , Backs, Johannes (Author) , Schirmacher, Peter (Author) , Schuppan, Detlef (Author) , Roth, Wilfried (Author) , Straub, Beate Katharina (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Cells
Year: 2023, Volume: 12, Issue: 1, Pages: 1-26
ISSN:2073-4409
DOI:10.3390/cells12010073
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/cells12010073
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2073-4409/12/1/73
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Author Notes:Hagen Roland Witzel, Inga Maria Gertrud Schwittai, Nils Hartmann, Sebastian Mueller, Jörn M. Schattenberg, Xue-Min Gong, Johannes Backs, Peter Schirmacher, Detlef Schuppan, Wilfried Roth and Beate Katharina Straub
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Summary:The single nucleotide polymorphism I148M of the lipase patatin-like phospholipase domain containing 3 (PNPLA3) is associated with an unfavorable prognosis in alcoholic and non-alcoholic steatohepatitis (ASH, NASH), with progression to liver cirrhosis and development of hepatocellular carcinoma. In this study, we investigated the mechanistic interaction of PNPLA3 with lipid droplet (LD)-associated proteins of the perilipin family, which serve as gatekeepers for LD degradation.
Item Description:Online veröffentlicht am 24. Dezember 2022
Gesehen am 21.02.2023
Physical Description:Online Resource
ISSN:2073-4409
DOI:10.3390/cells12010073

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