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Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases

We measured circulating serum and cerebrospinal fluid (CSF) concentrations of B lymphocyte activating factor of the tumour necrosis factor superfamily (BAFF), and determined total and Epstein-Barr virus (EBV)-specific oligoclonal IgG bands (OCBs) in 43 patients with multiple sclerosis (MS), 23 patie...

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Hauptverfasser: Franciotta, Diego (VerfasserIn) , Di Stefano, Anna Luisa (VerfasserIn) , Jarius, Sven (VerfasserIn) , Zardini, Elisabetta (VerfasserIn) , Tavazzi, Eleonora (VerfasserIn) , Ballerini, Clara (VerfasserIn) , Marchioni, Enrico (VerfasserIn) , Bergamaschi, Roberto (VerfasserIn) , Ceroni, Mauro (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2011
In: Journal of neuroimmunology
Year: 2011, Jahrgang: 230, Heft: 1/2, Pages: 160-163
ISSN:1872-8421
DOI:10.1016/j.jneuroim.2010.10.027
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jneuroim.2010.10.027
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165572810004777
Volltext
Verfasserangaben:Diego Franciotta, Anna Luisa Di Stefano, Sven Jarius, Elisabetta Zardini, Eleonora Tavazzi, Clara Ballerini, Enrico Marchioni, Roberto Bergamaschi, Mauro Ceroni
Beschreibung
Zusammenfassung:We measured circulating serum and cerebrospinal fluid (CSF) concentrations of B lymphocyte activating factor of the tumour necrosis factor superfamily (BAFF), and determined total and Epstein-Barr virus (EBV)-specific oligoclonal IgG bands (OCBs) in 43 patients with multiple sclerosis (MS), 23 patients with other inflammatory demyelinating neurological diseases, and 20 patients with non-inflammatory neurological diseases. Serum and CSF BAFF concentrations did not differ in the three studied groups. In MS, the highest BAFF concentrations were found in the CSF samples with more than 6 OCBs (233.1±129.5 vs 79.2±51.6pg/mL in the samples with less than 7 OCBs, p<0.0001). Irrespectively from BAFF levels, EBV-specific OCBs were detected in MS and in the other non-inflammatory and inflammatory demyelinating neurological diseases, with a similar frequency, and as a ‘mirror pattern’ in 30 of 33 EBV-specific OCB-positive cases (p<0.0001). These results indicate that circulating CSF BAFF concentrations cannot help differentiate MS from other inflammatory demyelinating neurological diseases, but positively associates with the qualitative expression of elevated intrathecal IgG production in MS, and that the oligoclonal EBV-specific antibody response, when present, is mostly systemic in all the studied neurological patients, and not preferentially restricted to MS.
Beschreibung:Online verfügbar 24 November 2010
Gesehen am 21.02.2023
Beschreibung:Online Resource
ISSN:1872-8421
DOI:10.1016/j.jneuroim.2010.10.027

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