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The antioxidant Rutin counteracts the pathological impact of α-synuclein on the enteric nervous system in vitro

Motoric disturbances in Parkinson’s disease (PD) derive from the loss of dopaminergic neurons in the substantia nigra. Intestinal dysfunctions often appear long before manifestation of neuronal symptoms, suggesting a strong correlation between gut and brain in PD. Oxidative stress is a key player in...

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Main Authors: Christmann, Anne (Author) , Gries, Manuela (Author) , Scholz, Patrik (Author) , Stahr, Pascal-Lothar (Author) , Law, Jessica Ka Yan (Author) , Schulte, Steven (Author) , Martin, Monika (Author) , Lilischkis, Rainer (Author) , Ingebrandt, Sven (Author) , Keck, Cornelia M. (Author) , Schäfer, Karl Herbert (Author)
Format: Article (Journal)
Language:English
Published: 2022
In: Biological chemistry
Year: 2022, Volume: 403, Issue: 1, Pages: 103-122
ISSN:1437-4315
DOI:10.1515/hsz-2021-0259
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1515/hsz-2021-0259
Verlag, lizenzpflichtig, Volltext: https://www.degruyterbrill.com/document/doi/10.1515/hsz-2021-0259/html
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Author Notes:Anne Christmann, Manuela Gries, Patrik Scholz, Pascal L. Stahr, Jessica Ka Yan Law, Steven Schulte, Monika Martin, Rainer Lilischkis, Sven Ingebrandt, Cornelia M. Keck, Karl-Herbert Schäfer
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Summary:Motoric disturbances in Parkinson’s disease (PD) derive from the loss of dopaminergic neurons in the substantia nigra. Intestinal dysfunctions often appear long before manifestation of neuronal symptoms, suggesting a strong correlation between gut and brain in PD. Oxidative stress is a key player in neurodegeneration causing neuronal cell death. Using natural antioxidative flavonoids like Rutin, might provide intervening strategies to improve PD pathogenesis. To explore the potential effects of micro (mRutin) compared to nano Rutin (nRutin) upon the brain and the gut during PD, its neuroprotective effects were assessed using an in vitro PD model. Our results demonstrated that Rutin inhibited the neurotoxicity induced by A53T α -synuclein (Syn) administration by decreasing oxidized lipids and increasing cell viability in both, mesencephalic and enteric cells. For enteric cells, neurite outgrowth, number of synaptic vesicles, and tyrosine hydroxylase positive cells were significantly reduced when treated with Syn. This could be reversed by the addition of Rutin. nRutin revealed a more pronounced result in all experiments. In conclusion, our study shows that Rutin, especially the nanocrystals, are promising natural compounds to protect neurons from cell death and oxidative stress during PD. Early intake of Rutin may provide a realizable option to prevent or slow PD pathogenesis.
Item Description:Veröffentlicht von De Gruyter 29. September 2021
Gesehen am 21.02.2023
Physical Description:Online Resource
ISSN:1437-4315
DOI:10.1515/hsz-2021-0259

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