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Redox responses in patients with sepsis: high correlation of Thioredoxin-1 and macrophage migration inhibitory factor plasma levels

Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock ( ) were collected at the time of sepsis diagnosis (t0),...

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Main Authors: Brenner, Thorsten (Author) , Rosenhagen, Claudia (Author) , Steppan, Jochen (Author) , Lichtenstern, Christoph (Author) , Weitz, Jürgen (Author) , Bruckner, Thomas (Author) , Martin, Eike (Author) , Hoffmann, Ursula (Author) , Weigand, Markus A. (Author) , Hofer, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 05 Aug 2010
In: Mediators of inflammation
Year: 2010, Volume: 2010, Pages: 1-8
ISSN:1466-1861
DOI:10.1155/2010/985614
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1155/2010/985614
Verlag, lizenzpflichtig, Volltext: https://www.hindawi.com/journals/mi/2010/985614/
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Author Notes:Thorsten Brenner, Claudia Rosenhagen, Jochen Steppan, Christoph Lichtenstern, Jürgen Weitz, Thomas Bruckner, Eike O. Martin, Ursula Hoffmann, Markus A. Weigand, and Stefan Hofer
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Summary:Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock ( ) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers ( ) were collected once; samples from postoperative patients ( ) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: : ). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response.
Item Description:Gesehen am 24.02.2023
Physical Description:Online Resource
ISSN:1466-1861
DOI:10.1155/2010/985614

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