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Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice

Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of periphera...

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Bibliographic Details
Main Authors: Eck, Wolfgang (Author) , Nicholson, Anthony I. (Author) , Zentgraf, Hanswalter (Author) , Semmler, Wolfhard (Author) , Bartling, Sönke (Author)
Format: Article (Journal)
Language:English
Published: 05/24/2010
In: Nano letters
Year: 2010, Volume: 10, Issue: 7, Pages: 2318-2322
ISSN:1530-6992
DOI:10.1021/nl101019s
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/nl101019s
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Author Notes:Wolfgang Eck, Anthony I. Nicholson, Hanswalter Zentgraf, Wolfhard Semmler, and Sönke Bartling
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Summary:Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of peripheral lymph nodes. This study demonstrates the general feasibility of biologically specific X-ray imaging in living animals and discusses basic requirements for the use of nanoparticles as a targeted X-ray contrast agent.
Item Description:Gesehen am 28.02.2023
Physical Description:Online Resource
ISSN:1530-6992
DOI:10.1021/nl101019s

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