Cover Image

Differential expression of the TRAIL/TRAIL-receptor system in patients with inflammatory bowel disease

TNF-related apoptosis inducing-ligand (TRAIL) is a potent inducer of apoptosis and plays an important role in immune regulation. To explore the role of TRAIL in inflammatory bowel disease (IBD), we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ul...

Full description

Saved in:
Bibliographic Details
Main Authors: Brost, Sylvia (Author) , Koschny, Ronald (Author) , Sykora, Jaromir (Author) , Stremmel, Wolfgang (Author) , Lasitschka, Felix (Author) , Walczak, Henning (Author) , Ganten, Tom M. (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Pathology, research and practice
Year: 2010, Volume: 206, Issue: 1, Pages: 43-50
ISSN:1618-0631
DOI:10.1016/j.prp.2009.09.005
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.prp.2009.09.005
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0344033809002623
Get full text
Author Notes:Sylvia Brost, Ronald Koschny, Jaromir Sykora, Wolfgang Stremmel, Felix Lasitschka, Henning Walczak, Tom M. Ganten
Description
Summary:TNF-related apoptosis inducing-ligand (TRAIL) is a potent inducer of apoptosis and plays an important role in immune regulation. To explore the role of TRAIL in inflammatory bowel disease (IBD), we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn's disease in comparison to normal colon and appendicitis. TRAIL and TRAIL-receptor (TRAIL-R) expression was assessed in resections of normal colon, colon of IBD patients, and appendicitis by immunohistochemistry. TRAIL was downregulated in enterocytes of patients with IBD, but was upregulated in mononuclear cells in areas of active mucosal inflammation. For TRAIL-R1, we detected a strong downregulation in the surface epithelium in IBD but not in appendicitis. TRAIL-R2 and TRAIL-R4 were strongly downregulated in the surface epithelium in any kind of mucosal inflammation. TRAIL and TRAIL-R1 are downregulated in enterocytes, and TRAIL is upregulated in mononuclear cells only in IBD but not in normal colon or appendicitis. This may point to a pathophysiologic role of the TRAIL system in inflammatory bowel disease.
Item Description:Erstmals am 1. Dezember 2009 online veröffentlicht
Gesehen am 01.03.2023
Physical Description:Online Resource
ISSN:1618-0631
DOI:10.1016/j.prp.2009.09.005

Similar Items