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68Ga-labelled recombinant antibody variants for immuno-PET imaging of solid tumours

Recombinant antibodies isolated from human antibody libraries have excellent affinities and high target specificity. As full-length IgGs are cleared inadequately slowly from the circulation, the aim of this work was to figure out which kind of recombinant antibody fragment proves to be appropriate f...

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Bibliographic Details
Main Authors: Eder, Matthias (Author) , Knackmuss, Stefan (Author) , Le Gall, Fabrice (Author) , Reusch, Uwe (Author) , Rybin, Vladimir (Author) , Little, Melvyn (Author) , Haberkorn, Uwe (Author) , Mier, Walter (Author) , Eisenhut, Michael (Author)
Format: Article (Journal)
Language:English
Published: 16 February 2010
In: European journal of nuclear medicine and molecular imaging
Year: 2010, Volume: 37, Issue: 7, Pages: 1397-1407
ISSN:1619-7089
DOI:10.1007/s00259-010-1392-6
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00259-010-1392-6
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Author Notes:Matthias Eder, Stefan Knackmuss, Fabrice Le Gall, Uwe Reusch, Vladimir Rybin, Melvyn Little, Uwe Haberkorn, Walter Mier, Michael Eisenhut
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Summary:Recombinant antibodies isolated from human antibody libraries have excellent affinities and high target specificity. As full-length IgGs are cleared inadequately slowly from the circulation, the aim of this work was to figure out which kind of recombinant antibody fragment proves to be appropriate for imaging epithelial cell adhesion molecule (EpCAM)-expressing tumours with the short-living radioisotope 68Ga.
Item Description:Im Titel ist die Zahl "68" hochgestellt
Gesehen am 02.03.2023
Physical Description:Online Resource
ISSN:1619-7089
DOI:10.1007/s00259-010-1392-6

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