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Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients

To identify molecularly defined subgroups in multiple myeloma, gene expression profiling was performed on purified CD138+ plasma cells of 320 newly diagnosed myeloma patients included in the Dutch-Belgian/German HOVON-65/GMMG-HD4 trial. Hierarchical clustering identified 10 subgroups; 6 corresponded...

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Main Authors: Broyl, Annemiek (Author) , Hose, Dirk (Author) , Lokhorst, Henk (Author) , Knegt, Yvonne de (Author) , Peeters, Justine (Author) , Jauch, Anna (Author) , Bertsch, Uta (Author) , Buijs, Arjan (Author) , Stevens-Kroef, Marian (Author) , Beverloo, H. Berna (Author) , Vellenga, Edo (Author) , Zweegman, Sonja (Author) , Kersten, Marie-Josée (Author) , Van der Holt, Bronno (Author) , Jarari, Laila El (Author) , Mulligan, George (Author) , Goldschmidt, Hartmut (Author) , Duin, Mark van (Author) , Sonneveld, Pieter (Author)
Format: Article (Journal)
Language:English
Published: October 7, 2010
In: Blood
Year: 2010, Volume: 116, Issue: 14, Pages: 2543-2553
ISSN:1528-0020
DOI:10.1182/blood-2009-12-261032
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood-2009-12-261032
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Author Notes:Annemiek Broyl, Dirk Hose, Henk Lokhorst, Yvonne de Knegt, Justine Peeters, Anna Jauch, Uta Bertsch, Arjan Buijs, Marian Stevens-Kroef, H. Berna Beverloo, Edo Vellenga, Sonja Zweegman, Marie-Josée Kersten, Bronno van der Holt, Laila el Jarari, George Mulligan, Hartmut Goldschmidt, Mark van Duin, and Pieter Sonneveld
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Summary:To identify molecularly defined subgroups in multiple myeloma, gene expression profiling was performed on purified CD138+ plasma cells of 320 newly diagnosed myeloma patients included in the Dutch-Belgian/German HOVON-65/GMMG-HD4 trial. Hierarchical clustering identified 10 subgroups; 6 corresponded to clusters described in the University of Arkansas for Medical Science (UAMS) classification, CD-1 (n = 13, 4.1%), CD-2 (n = 34, 1.6%), MF (n = 32, 1.0%), MS (n = 33, 1.3%), proliferation-associated genes (n = 15, 4.7%), and hyperdiploid (n = 77, 24.1%). Moreover, the UAMS low percentage of bone disease cluster was identified as a subcluster of the MF cluster (n = 15, 4.7%). One subgroup (n = 39, 12.2%) showed a myeloid signature. Three novel subgroups were defined, including a subgroup of 37 patients (11.6%) characterized by high expression of genes involved in the nuclear factor kappa light-chain-enhancer of activated B cells pathway, which include TNFAIP3 and CD40. Another subgroup of 22 patients (6.9%) was characterized by distinct overexpression of cancer testis antigens without overexpression of proliferation genes. The third novel cluster of 9 patients (2.8%) showed up-regulation of protein tyrosine phosphatases PRL-3 and PTPRZ1 as well as SOCS3. To conclude, in addition to 7 clusters described in the UAMS classification, we identified 3 novel subsets of multiple myeloma that may represent unique diagnostic entities.
Item Description:Gesehen am 02.03.2023
Physical Description:Online Resource
ISSN:1528-0020
DOI:10.1182/blood-2009-12-261032

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