Cover Image

Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancer

Antitumor inflammatory response is known to inhibit tumor growth in colorectal carcinoma. The density and functionality of tumor-infiltrating lymphocytes (TIL) is regulated by the antigen processing machinery through regulator proteins such as transporters associated with antigen processing (TAP) an...

Full description

Saved in:
Bibliographic Details
Main Authors: Kasajima, Atsuko (Author) , Sers, Christine (Author) , Sasano, Hironobu (Author) , Jöhrens, Korinna (Author) , Stenzinger, Albrecht (Author) , Noske, Aurelia (Author) , Buckendahl, Ann-Christin (Author) , Darb-Esfahani, Silvia (Author) , Müller, Berit Maria (Author) , Budczies, Jan (Author) , Lehman, Annika (Author) , Dietel, Manfred (Author) , Denkert, Carsten (Author) , Weichert, Wilko (Author)
Format: Article (Journal)
Language:English
Published: 23 September 2010
In: Human pathology
Year: 2010, Volume: 41, Issue: 12, Pages: 1758-1769
ISSN:1532-8392
DOI:10.1016/j.humpath.2010.05.014
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.humpath.2010.05.014
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0046817710002054
Get full text
Author Notes:Atsuko Kasajima, Christine Sers, Hironobu Sasano, Korinna Jöhrens, Albrecht Stenzinger, Aurelia Noske, Ann-Christin Buckendahl, Silvia Darb-Esfahani, Berit Maria Müller, Jan Budczies, Annika Lehman, Manfred Dietel, Carsten Denkert, Wilko Weichert
Description
Summary:Antitumor inflammatory response is known to inhibit tumor growth in colorectal carcinoma. The density and functionality of tumor-infiltrating lymphocytes (TIL) is regulated by the antigen processing machinery through regulator proteins such as transporters associated with antigen processing (TAP) and major histocompatibility complex (MHC) class I antigen. We aimed to investigate the in vivo association of those factors and their impact on prognosis in colorectal cancer.
Item Description:Gesehen am 02.03.2023
Physical Description:Online Resource
ISSN:1532-8392
DOI:10.1016/j.humpath.2010.05.014

Similar Items