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Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancer

Antitumor inflammatory response is known to inhibit tumor growth in colorectal carcinoma. The density and functionality of tumor-infiltrating lymphocytes (TIL) is regulated by the antigen processing machinery through regulator proteins such as transporters associated with antigen processing (TAP) an...

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Hauptverfasser: Kasajima, Atsuko (VerfasserIn) , Sers, Christine (VerfasserIn) , Sasano, Hironobu (VerfasserIn) , Jöhrens, Korinna (VerfasserIn) , Stenzinger, Albrecht (VerfasserIn) , Noske, Aurelia (VerfasserIn) , Buckendahl, Ann-Christin (VerfasserIn) , Darb-Esfahani, Silvia (VerfasserIn) , Müller, Berit Maria (VerfasserIn) , Budczies, Jan (VerfasserIn) , Lehman, Annika (VerfasserIn) , Dietel, Manfred (VerfasserIn) , Denkert, Carsten (VerfasserIn) , Weichert, Wilko (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 23 September 2010
In: Human pathology
Year: 2010, Jahrgang: 41, Heft: 12, Pages: 1758-1769
ISSN:1532-8392
DOI:10.1016/j.humpath.2010.05.014
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.humpath.2010.05.014
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0046817710002054
Volltext
Verfasserangaben:Atsuko Kasajima, Christine Sers, Hironobu Sasano, Korinna Jöhrens, Albrecht Stenzinger, Aurelia Noske, Ann-Christin Buckendahl, Silvia Darb-Esfahani, Berit Maria Müller, Jan Budczies, Annika Lehman, Manfred Dietel, Carsten Denkert, Wilko Weichert
Beschreibung
Zusammenfassung:Antitumor inflammatory response is known to inhibit tumor growth in colorectal carcinoma. The density and functionality of tumor-infiltrating lymphocytes (TIL) is regulated by the antigen processing machinery through regulator proteins such as transporters associated with antigen processing (TAP) and major histocompatibility complex (MHC) class I antigen. We aimed to investigate the in vivo association of those factors and their impact on prognosis in colorectal cancer.
Beschreibung:Gesehen am 02.03.2023
Beschreibung:Online Resource
ISSN:1532-8392
DOI:10.1016/j.humpath.2010.05.014

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