COX-2 expression and effects of COX-2 inhibition in colorectal carcinomas and their liver metastases
Nonsteroidal anti-inflammatory drugs are known to reduce the risk and mortality from colorectal carcinoma by inhibiting cyclo-oxygenases (COX). COX-2 expression was investigated immunohistologically in 57 patients with colorectal carcinomas and in the corresponding liver metastases using tissue micr...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 22, 2010
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| In: |
Anticancer research
Year: 2010, Volume: 30, Issue: 6, Pages: 2017-2023 |
| ISSN: | 1791-7530 |
| Online Access: | Verlag, kostenfrei, Volltext: https://ar.iiarjournals.org/content/30/6/2017
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| Author Notes: | Hans-Udo Kasper, Elisabeth Konze, Hans Peter Dienes, Dirk Ludger Stippel, Peter Schirmacher and Michael Kern |
| Summary: | Nonsteroidal anti-inflammatory drugs are known to reduce the risk and mortality from colorectal carcinoma by inhibiting cyclo-oxygenases (COX). COX-2 expression was investigated immunohistologically in 57 patients with colorectal carcinomas and in the corresponding liver metastases using tissue microarray analysis. Ex vivo COX-2 inhibition with assessment of apoptosis was performed using precision-cut tissue slices of three human liver metastases. Following stimulation with different concentrations of the selective COX-2 inhibitor meloxicam, apoptosis was assessed immunohistochemically after 6 h and 12 h. All primary carcinomas and 56 out of the 57 liver metastases showed various degrees of cytoplasmatic COX-2 expression being with a reduction and in the liver metastases. There was a time- and concentration-dependent change in the number of apoptotic cells in tissue slices, however, this was without statistical significance. COX-2 is constantly involved in the carcinogenesis and metastatic process of colorectal cancer. The antineoplastic effect of COX-2 inhibition may be based on different pathways, including changes in sensitivity to apoptosis. |
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| Item Description: | Gesehen am 07.03.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1791-7530 |